Mohamed H. Ramadan

TL;DR: Three-dimensional structures based on femurs, branched coronary arteries, trabeculated embryonic hearts, and human brains were mechanically robust and recreated complex 3D internal and external anatomical architectures.

TL;DR: Efficient and biologically effective MNA delivery of anti-TNF-α Ab to the intradermal microenvironment of the skin in mice and humans is demonstrated and these results support the development of MNA mediated antibody delivery of therapeutic antibodies for clinical applications.

TL;DR: It is concluded that PMEO2MA-grafted HA is a versatile platform for the passivation of hydrophobic biomaterial surfaces without need for substrate functionalization.

TL;DR: Results indicate TL-dMNAs can be successfully fabricated to integrate (anti-TNF-α-Ab)-HA at the tip portion of the microneedles while preserving the biological activity necessary for antibody ligand binding, and polymer conjugation effectively inhibits antibody diffusion from the delivery site.

TL;DR: Fundamental aspects of medical conditions that could be treated with cytokine-neutralizing polymer conjugates are discussed and design principles for preparing these cytokines neutralize to high molecular weight hydrophilic polymers are discussed.