Background The interest in the use of Eucalyptus genus members, in parallel with preclinical studies has been steadily growing over the last few decades in the field of pharmaceuticals, agriculture, cosmetics, food, etc. Eucalyptol (1,8-cineole or cineole), the main terpenoid constituent in Eucalyptus species, has been studied in both preclinical and clinical settings for its various pharmacologic activities. Investigations into the pharmacological activities of the genus Eucalyptus revealed that it manifests astounding potential in the treatment and management of respiratory disorders, COVID-19, pain, oral health, infectious diseases, cancer, etc. Purpose This review congregates and discusses the hitherto scattered data on Eucalyptus species morphology, chemical composition, some of its profusely investigated multifaceted therapeutic applications with insights into their molecular mechanisms, and clinical studies. The current understanding of the molecular mechanisms arising from cell lines, animal models, and clinical trials are emphasized. Lattermost, this review sheds light on various reported Eucalyptus-based formulations and relevant patents. Overall, this review aims to summarize and bridge the lacunae in the current research and offer a plethora of opportunities for the researchers engaged in the validation of the traditional claims and development in Eucalyptus utilization for safe and effective treatment of various diseases Method The systematic and comprehensive review was carried out by adhering to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements. PubMed, Scopus, ScienceDirect, Google Scholar, and Google patents databases were used to explore literature published till April 2021 by using relevant keywords. Results The systematic search retrieved 306 papers that were potentially relevant and after the selection procedure, 103 studies were included in this review and discussed. The evidence reviewed herein suggested that several Eucalyptus species possess anti-inflammatory, anti-microbial, anti-viral, anti-oxidant, anti-nociceptive, anti-cancer, anti-diabetic, etc., activities. Conclusion Preclinical and clinical studies have shown that the Eucalyptus plant and its chemical constituents have enormous potential for disease prevention and treatment. Eucalyptus, an ancient and underutilized ally with its diverse therapeutic applications can give rise to a paradigm shift in the treatment regime of several diseases in this era of modern science.

A systematic and comprehensive review on current understanding of the pharmacological actions, molecular mechanisms, and clinical implications of the genus Eucalyptus

This study was carried out to provide the baseline data on the composition and distribution of the angiosperms and to assess their current status in Rajkandi Reserve Forest of Moulvibazar, Bangladesh. The study reports a total of 549 angiosperm species belonging to 123 families, 98 (79.67%) of which consisting of 418 species under 316 genera belong to Magnoliopsida (dicotyledons), and the remaining 25 (20.33%) comprising 132 species of 96 genera to Liliopsida (monocotyledons). Rubiaceae with 30 species is recognized as the largest family in Magnoliopsida followed by Euphorbiaceae with 24 and Fabaceae with 22 species; whereas, in Lilliopsida Poaceae with 32 species is found to be the largest family followed by Cyperaceae and Araceae with 17 and 15 species, respectively. Ficus is found to be the largest genus with 12 species followed by Ipomoea, Cyperus and Dioscorea with five species each. Rajkandi Reserve Forest is dominated by the herbs (284 species) followed by trees (130 species), shrubs (125species), and lianas (10 species). Woodlands are found to be the most common habitat of angiosperms. A total of 387 species growing in this area are found to be economically useful. 25 species listed in Red Data Book of Bangladesh under different threatened categories are found under Lower Risk (LR) category in this study area.

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An annotated checklist of the angiospermic flora of Rajkandi Reserve Forest of Moulvibazar, Bangladesh.

Molecular mechanism of the anti-inflammatory effects of plant essential oils: A systematic review.

Australian tropical plants have been a rich source of food (bush food) and medicine to the first Australians (Aboriginal people), who are believed to have lived for more than 50,000 years. Plants such as spreading sneezeweed (Centipeda minima), goat’s foot (Ipomoea pes-caprae), and hop bush (Dodonaea viscosa and D. polyandra) are a few popular Aboriginal medicinal plants. Thus far, more than 900 medicinal plants have been recorded in the tropical region alone, and many of them are associated with diverse ethnomedicinal uses that belong to the traditional owners of Aboriginal people. In our effort to find anti-inflammatory lead compounds in collaboration with Aboriginal communities from their medicinal plants, we reviewed 78 medicinal plants used against various inflammation and inflammatory-related conditions by Aboriginal people. Out of those 78 species, we have included only 45 species whose crude extracts or isolated pure compounds showed anti-inflammatory properties. Upon investigating compounds isolated from 40 species (for five species, only crude extracts were studied), 83 compounds were associated with various anti-inflammatory properties. Alphitolic acid, Betulinic acid, Malabaric acid, and Hispidulin reduced proinflammatory cytokines and cyclooxygenase enzymes (COX-1 and 2) with IC50 values ranging from 11.5 to 46.9 uM. Other promising anti-inflammatory compounds are Brevilin A (from Centipeda minima), Eupalestin, and 5′-methoxy nobiletin (from Ageratum conyzoides), Calophyllolide (from Calophyllum inophyllum), and Brusatol (from Brucea javanica). D. polyandra is one example of an Aboriginal medicinal plant from which a novel anti-inflammatory benzoyl ester clerodane diterpenoid compound was obtained (compound name not disclosed), and it is in the development of topical medicines for inflammatory skin diseases. Medicinal plants in the tropics and those associated with indigenous knowledge of Aboriginal people could be a potential alternative source of novel anti-inflammatory therapeutics.

/pdf/indigenous-uses-phytochemical-analysis-and-anti-inflammatory-2jvnmk59.pdf

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

East Pakistan district gazetteers

Pteridophytes growing in the Rajkandi Reserve Forest of Moulvibazar district were indentified and a total of 52 species belonging to 30 genera of 20 families have been documented. The family Pteridaceae with nine species was found to be the largest, which was followed by Polypodiaceae with seven, Tectariaceae with six and Thelypteridaceae with five species. The genus Pteris with six species was found as the largest, which was followed by Tectaria with five and Bolbitis , Lygodium and Selaginella , each with 3 species, and the rest of the genera consisted of two or one species. Most of the species were recorded from the woodlands and three species, viz ., Tectaria chattagramica and Cyathea gigantea enlisted in Red Data Book of Bangladesh (Khan et al ., 2001), were found as common in this reserve forest. Jahangirnagar University J. Biol. Sci. 5 (2): 27-40, 2016 (December)

/pdf/taxonomic-checklist-of-the-pteridophytes-of-rajkandi-reserve-4c5ezzzsln.pdf

Taxonomic checklist of the pteridophytes of Rajkandi Reserve Forest, Moulvibazar, Bangladesh

The objective of our present study is to scrutinize the analgesic and anti-inflammatory potentials of essential oil of Eucalyptus camaldulensis leaf using different in vivo assay models at doses of...

https://journals.sagepub.com/doi/pdf/10.1177/1934578X211007634

Mohammod Abdur Rahim

Papers

Taxonomic checklist of the pteridophytes of Rajkandi Reserve Forest, Moulvibazar, Bangladesh

Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies