Showing papers in "Natural Product Communications in 2021"
TL;DR: In this article, the authors identified several existing compounds that could serve as effective inhibitors of the SARS-CoV-2 main protease (Mpro), and thus prevent the Mpro from working effectively.
Abstract: Various computational studies, including in silico ones, have identified several existing compounds that could serve as effective inhibitors of the SARS-CoV-2 main protease (Mpro), and thus prevent...
35 citations
TL;DR: In this paper, the authors describe polyphenols as natural antioxidants with excellent biological activities, which have resulted in increasing attention being paid to research on antiaging and antioxidation.
Abstract: Quality-of-life improvements have resulted in increasing attention being paid to research on antiaging and antioxidation. Polyphenols are natural antioxidants with excellent biological activities, ...
28 citations
TL;DR: Hesperidin and hesperetin are flavonoids that are abundantly present as constituents of citrus fruits and have attracted attention as several computational methods, mostly docking stud...
Abstract: Hesperidin and hesperetin are flavonoids that are abundantly present as constituents of citrus fruits. These compounds have attracted attention as several computational methods, mostly docking stud...
24 citations
TL;DR: An in silico molecular docking and molecular dynamic simulation analysis of screened phytochemicals from a comprehensive list of Ayurvedic herbs/functional foods that are present in natural food products against key receptor proteins of severe acute respiratory syndrome coronavirus 2.
Abstract: With the current pandemic of the novel coronavirus disease 2019 (COVID-19) in hand, researchers around the globe are dexterously working to find the best suitable drug candidates and overcome vacci...
21 citations
TL;DR: This article analyzed the chemical compositions and evaluated the antioxidant and cytotoxic activities of essential oils (EO) of Eugenia patrisii (Epat), Epat, Esti, Myrcia splendens (Ms...
Abstract: This work analyzed the chemical compositions and evaluated the antioxidant and cytotoxic activities of essential oils (EO) of Eugenia patrisii (Epat), Eugenia stipitata (Esti), Myrcia splendens (Ms...
19 citations
TL;DR: Even after one and a half years since the outbreak of COVID-19, its complete and effective control is still far from being achieved despite vaccination drives, symptomatic management with available...
Abstract: Even after one and a half years since the outbreak of COVID-19, its complete and effective control is still far from being achieved despite vaccination drives, symptomatic management with available...
14 citations
TL;DR: In this article, the chemical composition of essential oils extracted from the aerial parts of two species of Juniperus was determined by Gas Chromatography-Mass Spectrometry (GC-MS).
Abstract: The chemical composition of essential oils (EOs) extracted from the aerial parts of 2 species of Juniperus was determined by Gas Chromatography-Mass Spectrometry (GC-MS). In total, 65 and 58 compou...
13 citations
TL;DR: Andrographis paniculata, a medicinal plant commonly used for symptomatic relief of the common cold, and its phychological properties have been investigated in this article.
Abstract: Drug repurposing is commonly employed in the search for potential therapeutic agents. Andrographis paniculata, a medicinal plant commonly used for symptomatic relief of the common cold, and its phy...
12 citations
TL;DR: In this paper, Melaleuca alternifolia (Maiden and Betche) Cheel (tea tree) oil and C. sinensis (L.) Osbeck (orange) oil was procured, and their chemical compositions were characterized by gas chromatography coupled with mass spectrometry, with co-injection using authentic samples.
Abstract: In this study, Melaleuca alternifolia (Maiden and Betche) Cheel (tea tree) oil and C. sinensis (L.) Osbeck (orange) oil was procured, and their chemical compositions were characterized by gas chromatography coupled with mass spectrometry, with co-injection using authentic samples. The oils were rich in monoterpene hydrocarbons making up 84.5% of C. sinensis and 48.9% of M. alternifolia oils. High amounts of oxygenated monoterpenoids were also identified in C. sinensis (9.6%) and M. alternifolia (49.3%) oils. The three most abundant compounds were limonene (71.2%), linalool (5.5%), and β-myrcene (5.1%) in C. sinensis, and terpinen-4-ol (45.6%), γ-terpinene (19.4%) and α-terpinene (9.3%) in M. alternifolia. Enzyme inhibitions (anticholinesterase, antiurease, antityrosinase) of both essential oils were evaluated. In acetylcholinesterase assay, M. alternifolia and C. sinensis had inhibition concentration (IC50) values of 153.7 ± 1.25 and 96.4 ± 1.0 µg/mL, respectively as compared to 5.42 ± 0.11 µg/mL for galantamine, while in butyrylcholinesterase assay, M. alternifolia (IC50 = 85.6 ± 0.7 µg/mL) and C. sinensis (IC50 = 127.8 ± 0.6 µg/mL) exhibited moderate activities compared to galantamine (IC50 = 45.8 ± 0.8 µg/mL). In the urease inhibitory activity, essential oils of C. sinensis and M. alternifolia showed 48.4% ± 0.9% and 30.6% ± 0.7% inhibitions at 200 µg/mL concentration, respectively. Quorum sensing (QS) mediated violacein production in Chromobacterium violaceum CV12472 was inhibited by 100% at minimum inhibitory concentration (MIC) values for both oils while showing QS inhibition diameter zones in C. violaceum of 22.5 ± 0.4 mm and 14.3 ± 0.5 mm for C. sinensis and M. alternifolia oils, respectively at MIC concentration. The good quorum-sensing potential indicates that these oils can suppress microbial resistance and severity of infections.
12 citations
TL;DR: Sargassum is a genus of brown macroalgae in the class Phaeophyta, distributed widely in all oceans, including those of Vietnam as mentioned in this paper, and has been proven to possess diverse biological properties.
Abstract: Sargassum is a genus of brown macroalgae in the class Phaeophyta, distributed widely in all oceans, including those of Vietnam. Species of this genus have been proven to possess diverse biological ...
11 citations
TL;DR: In this article, the authors considered the state of the art on the relation between manganese and bone health and found that the evidence regarding a deficiency of Manganese (Mn) in humans is scarce.
Abstract: The evidence regarding a deficiency of manganese (Mn) in humans is scarce. So the aim of this narrative review was to consider the state of the art on the relation between manganese and bone health...
TL;DR: In this article, the main objective of the study was to investigate the antibacterial activity and mechanism of Litsea cubeba essential oil (LCEO) against Acinetobacter baumannii.
Abstract: The main objective of this study was to investigate the antibacterial activity and mechanism of Litsea cubeba essential oil (LCEO) against Acinetobacter baumannii. The antibacterial activit...
TL;DR: Analysis of the essential oil compositions and enantiomeric ratios of predominant aromatic molecules add to the understanding of the medicinal phytochemistry of the genus Scutellaria.
Abstract: Scutellaria (skullcap) are important medicinal plants. Scutellaria baicalensis and S.barbata have been used in Chinese traditional medicine, while S. incana and S. lateriflora were used as herbal m...
TL;DR: Although demonstrated in 1975, vibrational circular dichroism (VCD) finally started to popularize during this century as a reliable tool to determine the absolute configuration (AC) of organic mole as discussed by the authors.
Abstract: Although demonstrated in 1975, vibrational circular dichroism (VCD) finally started to popularize during this century as a reliable tool to determine the absolute configuration (AC) of organic mole...
TL;DR: Reaction flow (RF) chromatography is a powerful and efficient approach that utilizes conventional high-performance liquid chromatography (HPLC) -ultraviolet (UV) visible detection as discussed by the authors.
Abstract: Reaction flow (RF) chromatography is a powerful and efficient approach that utilizes conventional high-performance liquid chromatography (HPLC)–ultraviolet (UV)–visible detection. This technique ex...
TL;DR: This review summarizes the literature data concerning structures and biological activities of all the new triterpene glycosides isolated from sea cucumbers during 2017 to 2021.
Abstract: Structural diversity of triterpene glycosides produced by sea cucumbers or holothurians (Holothuroidea, Echinodermata) is extremely high, although all of them are either lanostane derivatives or, r...
TL;DR: In this article, the authors scrutinize the analgesic and anti-inflammatory potentials of essential oil of Eucalyptus camaldulensis leaf using different in vivo assay models at doses of...
Abstract: The objective of our present study is to scrutinize the analgesic and anti-inflammatory potentials of essential oil of Eucalyptus camaldulensis leaf using different in vivo assay models at doses of...
TL;DR: This study reports for the first time the isolation of compounds 1 to 6 from the stem bark of Z leprieurii, and suggests trans-Fagaramide may present a vital template in pursuit of novel and highly effective TB drugs.
Abstract: Zanthoxylum leprieurii Guill. and Perr. (Rutaceae) stem bark is used locally in Uganda for treating tuberculosis (TB) and cough-related infections. Lupeol (1), sesamin (2), trans-fagaramide (3), ar...
TL;DR: The data clearly show that C. molle inhibited pancreatic, dermal, and DNA injury and improved the oxidative state in male rats, suggesting that the use of C.molle is a promising synergistic potential ameliorative agent in the diabetic animal model.
Abstract: The use of natural extracts in the treatment of diabetes mellitus has grown recently. In the current study, the immune-protecting effects and the hypoglycemic and antioxidant activities of Combretu...
TL;DR: In this article, the compositions of essential oil and DCM extract samples from 12 individual Boswellia frereana trees were characterized, and the triterpenoid fraction was largely consistent between samples, with lupeol (14.7%-32.5%), α-amyrin (13.0%-25.2%), 3-epi-lupeol (6.4%-14.2), and β-amrin (5.3%-8.0%) as the primary constituents.
Abstract: Frankincense is an aromatic terpenoid oleo-gum resin produced by trees in the genus Boswellia. It has been used for medicinal and religious purposes for millennia, and is today an important component in perfume and aromatherapy. The resin of Boswellia frereana is especially prized, and has been found to contain a high proportion of monoterpenes. However, previous studies have relied on commercial samples; in this study, we characterize the compositions of essential oil and DCM extract samples from 12 individual B frereana trees. The triterpenoid fraction was largely consistent between samples, with lupeol (14.7%-32.5%), α-amyrin (13.0%-25.2%), 3-epi-lupeol (6.4%-14.2%), and β-amyrin (5.3%-8.0%) as the primary constituents. The essential oil showed more intersample diversity, but still represented a single, variable chemotype characterized by a moderate to high level of α-thujene (14.5%-43.9%) and a varying, often significant, level of α-pinene (3.0%-63.0%).
TL;DR: Two new xanthone derivatives, spinosusones A and B, and a new tryptoquivaline analogue, asperdiazapinone G, together with nine known compounds were isolated from the EtOAc extract of the marine-derived fungus Aspergillus sp.
Abstract: Two new xanthone derivatives, spinosusones A (1) and B (2), and a new tryptoquivaline analogue, asperdiazapinone G (3), together with nine known compounds (4-12) were isolated from the EtOAc extrac...
TL;DR: Angelica sinensis Radix (ASR), one of the most commonly used traditional Chinese medicines, contains many chemical components such as polysaccharides, volatile oil, flavonoids, amino acids as discussed by the authors.
Abstract: Angelica sinensis Radix (ASR), one of the most commonly used traditional Chinese medicines, contains many chemical components such as polysaccharides, volatile oil, flavonoids, amino acids, and org...
TL;DR: This paper summarizes the targets and modes of action of the approved anti-tumor drugs while systematically discussing their synthetic routes for medicinal chemistry or industrial use, which will benefit next-generation drug discovery.
Abstract: Malignant tumors have become a significant public health problem that severely threatens human health. Drug-targeting therapy is essential for tumor therapy, along with surgery and radiotherapy. Of...
TL;DR: The drug resistance of Pseudomonas aeruginosa is a worldwide problem due to its great threat to human health A crude extract of Angelica dahurica has been proved to have antibacterial properties,.
Abstract: The drug resistance of Pseudomonas aeruginosa is a worldwide problem due to its great threat to human health A crude extract of Angelica dahurica has been proved to have antibacterial properties,
TL;DR: Leishmaniases are a spectrum of poverty-linked neglected parasitic diseases that are endemic in 88 countries around the globe and affect millions of people every year as mentioned in this paper, and can be treated with chemotherapy.
Abstract: Leishmaniases are a spectrum of poverty-linked neglected parasitic diseases that are endemic in 88 countries around the globe and affect millions of people every year. Currently available chemother...
TL;DR: Analysis of the therapeutic properties of FDY003, a herbal anti-ERPBC prescription, using a network pharmacology approach showed thatFDY003 may target a variety of ERPBC-associated pathways, including the PIK3-Akt, focal adhesion, MAPK, and estrogen pathways.
Abstract: Estrogen receptor-positive breast cancer (ERPBC) is the commonest subtype of breast cancer, with a high prevalence, incidence, and mortality. Herbal drugs are increasingly being used to treat ERPBC...
TL;DR: In this paper, a novel 1,4-pyranonaphthoquinone derivatives were successfully synthesized via the microwave-assisted three-component reaction of 1, 4-naphthoequinone, malononitrile, and various arylaldehydes in ethan...
Abstract: Novel 1,4-pyranonaphthoquinone derivatives were successfully synthesized via the microwave-assisted three-component reaction of 1,4-naphthoquinone, malononitrile, and various arylaldehydes in ethan...
TL;DR: In this article, repeated exposure to ionizing radiation has been reported to increase the risk of chronic metabolic disorders such as systemic hyperlipidemia and intracellular lipid accumulation that might lead to...
Abstract: Repeated exposure to ionizing radiation has been reported to increase the risk of chronic metabolic disorders such as systemic hyperlipidemia and intracellular lipid accumulation that might lead to...
TL;DR: In this article, the chemical composition of Passiflora sexocellata (Passifloraceae, subgenus Decaloba) was studied for the first time.
Abstract: The chemical composition of the essential oils of Passiflora sexocellata and Passiflora trifasciata (Passifloraceae, subgenus Decaloba) were studied for the first time. Essential oils were obtained...