Showing papers by "Mohd. Aqil published in 2019"
TL;DR: The developed thymoquinone loaded ethosomes formulation can be used as an effective treatment option for acne vulgaris and various skin disorders and was concluded that the developed formulation was safe, less irritant and well tolerable formulation for topical delivery.
55 citations
TL;DR: The in vivo study revealed that the mice pre‐treated with fisetin binary ethosomes gel caused marked decrease in the levels of TNF and IL‐1&agr; as compared to the mice exposed to UV only.
53 citations
TL;DR: It can be concluded that etoposide loaded SLN was able to maintain vitreous concentration of drug without any serious toxic effect to the surrounding ocular tissues after an intravitreous administration in rat eye.
40 citations
TL;DR: It was concluded that the independent variables used to optimize the NLs shown significant effect on the dependent variables and consider effective lipid carrier system for intranasal delivery.
31 citations
TL;DR: The behavioral studies confirmed that the antidepressant activity of agomelatine can be improved by loading the drug into a mucoadhesive-nanoemulsion-gel system followed by its intranasal administration.
27 citations
TL;DR: The results indicated that NBT-SNEDDS could be a potential carrier for an oral dosage form of NBT with enhanced relative bioavailability and therapeutic effects and presented an increased anti-inflammatory efficacy when compared with orally administered commercial product of N BT.
26 citations
TL;DR: It was concluded that the experimental design based AMNLCs showed the quadratic relationship between independent and dependent variables and also found to be a proficient carrier for transdermal delivery of amlodipine.
25 citations
TL;DR: In this article, the authors formulated and optimized Thymoquinone (TQ) lipid nanoparticles (NPs) formulations for the treatment of psoriasis, and the formulation optimization was performed using the independent variables (gelucire (A), capmul (B), sonication time(C), and their individual and combined effects were assessed on size (Z1), poly dispersity index (Z2), and drug encapsulation (Z3).
20 citations
TL;DR: It was concluded that the prepared transfersomes formulation was found to be a potentially useful drug carrier for the enhancement of raloxifene bioavailability in rats.
17 citations
TL;DR: The advantages of GA-loaded niosomes are concluded and the effectiveness of prepared formulation in controlling serum antioxidant, lipid profile and diabetic complications in experimentally induced DN in animals is explained via inhibiting of oxidative stress and “advanced glycation end products (AGE's)”.
15 citations
TL;DR: In this paper, a teriflunomide-loaded nanoliposomes by thin-film hydration technique for the management of rheumatoid arthritis was developed.
01 Jan 2019
TL;DR: This chapter overviews the use of QbD in transdermal and topical research areas and the perspectives and development priorities are drawn to improve the implementation of this integrative approach of quality and safety intransdermal delivery systems.
Abstract: Pharmaceutical quality by design (QbD) widely used in the optimization of transdermal and topical delivery systems. These approaches mainly depend upon the understanding of both the product and the process. The purpose of this chapter is to provide a background of different QbD approach in different transdermal drug delivery systems (TDDS). The optimization processes is required for an accurate research in these fields and therefore, the right implementation is carried out for different design approach at industrial scale. This chapter overviews the use of QbD in transdermal and topical research areas. The perspectives and development priorities are drawn to improve the implementation of this integrative approach of quality and safety in transdermal delivery systems.
01 Jan 2019
TL;DR: Chitosan is a biodegradable, biocompatible polysaccharide polymer with anti-infective, antidiabetic, anticancer, and antihyperlipidemic effect and shows strong mucoadhesive property by interacting with negatively charged entity of skin moieties, thus prolonging contact time.
Abstract: Transdermal drug delivery has offered a promising alternative to other routes of delivery especially for the lipophilic drugs with limited oral bioavailability. Transdermal systems are acceptable because of their noninvasiveness, ease of application and removal, controlled drug release for long duration of time, avoidance of hepatic first-pass metabolism, and improved bioavailability. The predominant challenge in transdermal drug delivery is the skin barrier in the form of stratum corneum. Various approaches have been employed for breaching this barrier including penetration enhancers, iontophoresis, electroporation, and sonophoresis to name a few. Chitosan is a biodegradable, biocompatible polysaccharide polymer with anti-infective, antidiabetic, anticancer, and antihyperlipidemic effect. It has also been used as an adjuvant in transdermal drug delivery for its skin penetration enhancing properties. It is polycationic in nature and shows strong mucoadhesive property by interacting with negatively charged entity of skin moieties, thus prolonging contact time. This chapter deals with the synthesis of chitosan and application of chitosan-based drug delivery systems in transdermal drug delivery.