Monica Ek

TL;DR: It is shown that cerebral vascular cells express components enabling a blood-borne cytokine to stimulate the production of prostaglandin E2, an inflammatory mediator whose small size and lipophilic properties allow it to diffuse into the brain parenchyma.

TL;DR: Results suggest that refinement of M. x giganteus via organosolv processes could potentially turn this grass into a valuable source of both fiber and lignin.

TL;DR: Findings are consistent with the view that increased circulating IL‐1 may stimulate central neural mechanisms, including hypothalamic CRH neurons, through an EP3R‐dependent mechanism involving PGE2‐mediated activation of cells in the caudal medulla and/or preoptic region.

TL;DR: The increased expression of the Ro52 autoantigen in patients may be directly involved in the reduced cellular proliferation and increased apoptotic cell death observed in Sjögren’s syndrome and SLE, and may thus contribute to theAutoantigenic load and induction of autoimmune B and T cell responses observed in rheumatic patients.

TL;DR: The high amount of extracellular HMGB-1 observed in skin lesions indicates that HMGB -1 is involved in the inflammatory process of CLE, underscoring the role of the target organ in the rheumatoid autoimmune inflammatory process.