P
Paul E. Sawchenko
Researcher at Salk Institute for Biological Studies
Publications - 194
Citations - 44425
Paul E. Sawchenko is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Hypothalamus & Vasopressin. The author has an hindex of 99, co-authored 194 publications receiving 43151 citations.
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Journal ArticleDOI
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Michael G. Rosenfeld,Jean-Jacques Mermod,Susan G. Amara,Larry W. Swanson,Paul E. Sawchenko,Jean Rivier,Wylie Vale,Ronald M. Evans +7 more
TL;DR: The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.
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Organization of Ovine Corticotropin-Releasing Factor Immunoreactive Cells and Fibers in the Rat Brain: An Immunohistochemical Study
TL;DR: The results suggest that the PVH plays a critical role in the modulation of ACTH and beta-endorphin release from the pituitary, and that CRF-containing pathways in the brain are involved in the mediation of autonomic responses.
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Hypothalamic Integration: Organization of the Paraventricular and Supraoptic Nuclei
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Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
Joan Vaughan,Cynthia J. Donaldson,Jackson C. Bittencourt,Marilyn H. Perrin,Kathy A. Lewis,Steven W. Sutton,Raymond K. W. Chan,Andrew V. Turnbull,David A. Lovejoy,Catherine Rivier,Jean Rivier,Paul E. Sawchenko,Wylie Vale +12 more
TL;DR: This work characterized another mammalian member of the CRF family and localized its urotensin-like immunoreactivity to, and cloned related complementary DNAs from, a discrete rat midbrain region, and deduced a peptide that is related to u Rotensin and CRF, which is named urocortin, which could be an endogenous ligand for type-2 CRF receptors.
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Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat
TL;DR: The results indicate that both oxytocin‐ and vasopressin‐stained cells in the PVH project to the spinal cord and to the dorsal vagal complex, although about three times as many oxytocinstained cells were doubly labeled after injections centered in either terminal field, suggesting that additional neuroactive substances are contained within these pathways.