M
Monica Paravidino
Researcher at VU University Amsterdam
Publications - 12
Citations - 207
Monica Paravidino is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Peptidomimetic & Metathesis. The author has an hindex of 7, co-authored 12 publications receiving 195 citations. Previous affiliations of Monica Paravidino include Delft University of Technology.
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Journal ArticleDOI
Enzymatic acylation: assessing the greenness of different acyl donors
Monica Paravidino,Ulf Hanefeld +1 more
TL;DR: This review aims at screening the actual number of applications of the different acyl donors, and at assessing the “greenness” (or lack thereof) of the most applied among them, using an efficient tool in strategic planning, a strengths-weaknesses-opportunities-threats (SWOT) analysis.
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A Flexible Six-Component Reaction To Access Constrained Depsipeptides Based on a Dihydropyridinone Core
Monica Paravidino,Rachel Scheffelaar,Rob F. Schmitz,Frans J. J. de Kanter,Marinus B. Groen,Eelco Ruijter,Romano V. A. Orru +6 more
TL;DR: Highly functionalized and conformationally constrained depsipeptides based on a dihydropyridin-2-one core are prepared by the combination of a four- and a three-component reaction.
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Synthesis of conformationally constrained peptidomimetics using multicomponent reactions.
Rachel Scheffelaar,Roel A. Klein Nijenhuis,Monica Paravidino,Martin Lutz,Anthony L. Spek,Andreas W. Ehlers,Frans J. J. de Kanter,Marinus B. Groen,Romano V. A. Orru,Eelco Ruijter +9 more
TL;DR: A novel modular synthetic approach toward constrained peptidomimetics that involves a highly efficient three-step sequence including two multicomponent reactions, thus allowing unprecedented diversification of both the peptide moieties and the turn-inducing scaffold is reported.
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Scope and limitations of an efficient four-component reaction for dihydropyridin-2-ones
Rachel Scheffelaar,Monica Paravidino,Anass Znabet,Rob F. Schmitz,Frans J. J. de Kanter,Martin Lutz,Anthony L. Spek,Célia Fonseca Guerra,F. Matthias Bickelhaupt,Marinus B. Groen,Eelco Ruijter,Romano V. A. Orru +11 more
TL;DR: A broad range of isonitrile-functionalized 3,4-dihydropyridin-2-ones could be prepared using a four-component reaction between phosphonates, nitriles, aldehydes, and isocyanoacetates, but variation of the phosphonate input remains limited.
Journal ArticleDOI
Asymmetrized tris(hydroxymethyl)methane as a precursor of N- and O-containing 6-membered heterocycles through ring-closing metathesis.
TL;DR: A novel synthetic application of asymmetrized tris(hydroxymethyl)methane (THYM), obtained in both enantiomeric forms in high e.