Rob F. Schmitz

TL;DR: The three-component condensation between an amine, an aldehyde, and an alpha-acidic isocyanide efficiently provides substituted 2-imidazolines in a one-pot reaction under mild conditions.

TL;DR: A multicomponent reaction between alpha-acidic isonitriles, primary amines, and carbonyl compounds was studied using 14 different solvents, resulting in a fast, easy to perform, and resource-efficient protocol for this three-component reaction.

TL;DR: A broad range of differently substituted dihydropyrimidines and thiazines can be efficiently prepared by using a four-component reaction between phosphonates, nitriles, aldehydes, and iso(thio)cyanates, which seems to be restricted to the use of isocyanates with strongly electron-withdrawing substituents.

TL;DR: Optimization of Radziszewski's four-component reaction employing a microwave-assisted protocol, led to a small library of 48 imidazoles with a success rate of 65% (conversion > 45%) and a reaction mechanism is proposed.

TL;DR: In a search for new multicomponent strategies leading to valuable small heterocycles, a new highly diastereoselective four-component reaction (4CR) was found in which a phosphonate, nitriles, aldehydes, and isocyanoacetates combine to afford functionalized 3-isOCyano-3,4-dihydro-2-pyridones.