Monika Bubka

TL;DR: The data show that alpha3beta1 integrin function may be altered by glycosylation, that both subunits contribute to these changes, and that gly cosylation may be considered a newly found mechanism in the regulation of integrinfunction.

TL;DR: This is the first report concerning structural characterisation of alpha(v)beta3 integrin glycans in melanoma or in any cancer cells, and the N-oligosaccharide component of the tested integrins influenced melanoma cell migration on vitronectin and alpha3beta1 integrin binding to laminin-5.

TL;DR: The results show that the acquisition of metastatic competence by melanoma cells is accompanied by alteration of αv β3 integrin glycosylation and that both αvβ3 and β1-6-branched sialylated complex-type N-glycans promote metastatic melanoma migration on VN.

TL;DR: The present review highlights the ways in which particular tumor-associated glycan(s) coupled with a given membrane-bound protein influence neoplastic cell behavior during the development and progression of cancer.

TL;DR: Results revealed, ERRs indirectly regulate Leydig cell proliferation while ERRα and β affect cell monolayer formation, and ERRs should be considered important factors in developing of innovating approaches that target pathological processes of testicular Leydigs cells.