Monte J. Radeke

TL;DR: Taniuchi et al. as discussed by the authors found that the levels of nerve growth factor (NGF) mRNA (mRNANGF) and NGF receptor mRNA(mRNA(rec)) in the sciatic nerve were 10 and 120 times higher, respectively, than in adult animals.

TL;DR: This article revisits the original hypothesis that chronic local inflammatory and immune-mediated events at the level of Bruch's membrane play critical roles in drusen biogenesis and, by extension, in the pathobiology of AMD, and identifies and characterize the local complement system in the RPE-choroid complex.

TL;DR: The detection of TrkB immunoreactivity on cell bodies and dendrites is consistent with recent models suggesting that neurotrophins may be derived from presynaptic and/or autocrine sources in addition to the classical postsynaptic target.

TL;DR: It is shown that Aβ is associated with a substructural vesicular component within drusen, which could be an important component of the local inflammatory events that contribute to atrophy of the retinal pigmented epithelium, Drusen biogenesis, and the pathogenesis of AMD.

TL;DR: The dendritic localization of trkB receptors supports the hypothesis that dendrites, as well as axons, are important sites for neurotrophin actions in the central nervous system.