Montse Morlá

TL;DR: It is confirmed that smoking exposure enhances telomere shortening in circulating lymphocytes and a dose–effect relationship between exposure to tobacco smoking and telomeres length is demonstrated, but it is failed to show that this effect is amplified in smokers who develop chronic obstructive pulmonary disease.

TL;DR: Investigating whether activation of the nuclear transcription factor NF-κB and upregulation of the inducible form of nitric oxide synthase (iNOS) occur in the skeletal muscle of patients with COPD and low body weight found changes might contribute to the molecular pathogenesis of cachexia in COPD.

TL;DR: The results of the current study confirm that smoking exposure enhances telomere shortening in circulating lymphocytes and demonstrates a dose-effect relationship between exposure to tobacco smoking and telomeres length, but fails to show that this effect is amplified in smokers who develop chronic obstructive pulmonary disease.

TL;DR: This is the first human mutation showing that TBX1 is a candidate causing mental retardation associated with the 22q11.2 duplication syndrome and an easy and quick way to do it with an amplification refractory mutation system (ARMS) approach is provided.

TL;DR: It is demonstrated that TNF-alpha directly induces apoptosis in differentiated myotubes and suggested that the cytokine IFN-gamma, might represent a new immunoadjuvant therapeutic tool for managing cachexia.