Morgane Bayle

TL;DR: Animal and in vitro studies selected in this review highlight the direct action of polyphenols on pancreatic β-cells, stimulating insulin secretion through the activation of specific cellular targets and protecting these cells from damages mediated by oxidative stress and inflammation, both typically elevated in diabetes.

TL;DR: This highly specific and sensitive liquid chromatography-electrospray ionization-tandem mass spectrometry method for the determination of urolithin C in rat plasma was used to analyze samples collected during preclinical pharmacokinetic studies in rats.

TL;DR: It is reported that urolithin C enhanced glucose‐induced extracellular signal‐regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS‐1 β‐cells, indicating that the pharmacological action of urolithsin C on insulin secretion relies, in part, on its capacity to enhance glucose‐ induced ERK1 /2 activation.

TL;DR: In this paper, Liver-Expressed Antimicrobial Peptide 2 (LEAP2) was recognized as an endogenous G-protein coupled receptor (GPCR) ligand that blocks ghrelin-induced actions.

TL;DR: In this paper , a triazole-derived modulator of growth hormone secretagogue receptor (GHSR) is proposed to mitigate several pathological features associated with eating and metabolic disorders.