Journal ArticleDOI
Protection of pancreatic β-cell function by dietary polyphenols
Margherita Dall'Asta,Morgane Bayle,Jérémie Neasta,Francesca Scazzina,Renato Bruni,Gérard Cros,Daniele Del Rio,Daniele Del Rio,Catherine Oiry +8 more
TLDR
Animal and in vitro studies selected in this review highlight the direct action of polyphenols on pancreatic β-cells, stimulating insulin secretion through the activation of specific cellular targets and protecting these cells from damages mediated by oxidative stress and inflammation, both typically elevated in diabetes.Abstract:
Diabetes mellitus is a complex metabolic disorder and is considered a fast-growing global health problem. Type 2 diabetes (T2D) represents the majority of total diabetes prevalence and β-cell dysfunction has been described as a crucial point for this disease development and progression. To date, all of the common anti-hyperglycaemic drugs used for diabetes management cause undesirable side effects or problems with long-term efficacy or safety and the development of alternative approaches for the prevention as well as for the treatment of T2D might be a valuable solution to meet this rising demand. In this regards, numerous epidemiological studies indicate that exposure to certain polyphenol compounds is associated with the prevention of chronic diseases, including diabetes. Here, we review growing evidence suggesting that polyphenols can modulate the activity of various molecular targets, which are known to control β-cell function, involved in the development and the progression of this diabetes. The protective effects of polyphenols on β-cell function is reported with a particular focus on the mechanism of action behind polyphenol putative bioactivity. Animal and in vitro studies selected in this review, reporting about both flavonoid and non-flavonoid compounds, highlight the direct action of polyphenols on pancreatic β-cells, stimulating insulin secretion through the activation of specific cellular targets and protecting these cells from damages mediated by oxidative stress and inflammation, both typically elevated in diabetes. Some of the reviewed studies describe polyphenol effects comparable to those exerted by many drugs commonly used in diabetes treatment, and, in some occasions, synergistic polyphenol-drug interactions. Finally, future studies need to be addressed to the effects of specific polyphenol human and microbial metabolites, which are still poorly studied, in order to better define the preventive and therapeutic approach to contrast β-cell failure and diabetes progression.read more
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Journal ArticleDOI
At the interface of antioxidant signalling and cellular function: Key polyphenol effects.
Asimina Kerimi,Gary Williamson +1 more
TL;DR: The molecular mechanisms for 3 actions of (poly)phenols on oxidative processes where there is evidence in vivo from human intervention or animal studies are reviewed.
Journal ArticleDOI
Antidiabetic potential of dietary polyphenols: A mechanistic review.
David de Paulo Farias,Fábio Fernandes de Araújo,Iramaia Angélica Neri-Numa,Glaucia Maria Pastore +3 more
TL;DR: In this article, the potential of phenolic compounds on diabetes management, addressing their mechanisms of action, in addition to discussing the digestion, absorption, metabolism, bioavailability, and toxic effects of these compounds.
Journal ArticleDOI
The Ellagitannin Metabolite Urolithin C is a Glucose‐Dependent Regulator of Insulin Secretion through activation of L‐type Calcium Channels
Morgane Bayle,Jérémie Neasta,Margherita Dall'Asta,Guillaume Gautheron,Anne Virsolvy,Jean-François Quignard,Estelle Youl,Richard Magous,Jean-François Guichou,Alan Crozier,Alan Crozier,Daniele Del Rio,Gérard Cros,Catherine Oiry +13 more
TL;DR: This work has sought to identify polyphenol metabolites that enhance the insulin‐secreting function of beta‐cells and to explore the underlying mechanisms.
Book ChapterDOI
Fruits: A Source of Polyphenols and Health Benefits
TL;DR: The most studied polyphenols include quercetin, present in berries and grapes, which have beneficial effects on diabetes, cancer, and metabolic diseases; another example is hesperidin in citrus, which has antiinflammatory and analgesic effects as mentioned in this paper.
Journal ArticleDOI
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
Te Du,Liu Yang,Xu Xu,Xiaofan Shi,Xin Xu,Jian Lu,Jianlu Lv,Xi Huang,Jing Chen,Heyao Wang,Ji-Ming Ye,Lihong Hu,Xu Shen,Xu Shen +13 more
TL;DR: Interestingly, it is found that vincamine could protect INS-832/13 cells function by regulating G-protein-coupled receptor 40 (GPR40)/cAMP/Ca2+/IRS2/PI3K/Akt signaling pathway, while increasing glucose-stimulated insulin secretion (GSIS) by modulating GPR40/cAMP/.
References
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