Morgane Griesbeck

TL;DR: This refined analysis has identified, among others, a previously unknown dendritic cell population that potently activates T cells and reclassify pDCs as the originally described “natural interferon-producing cells (IPCs)” with weaker T cell proliferation induction ability.

TL;DR: In this paper, the authors performed single-cell RNA sequencing of ~2400 cells isolated from healthy blood donors and enriched for HLA-DR + lineage − cells, which led them to identify and validate six Dendritic cells (DCs) and four monocyte subtypes.

TL;DR: Higher IFN-α production is associated with higher ex vivo expression of several ISGs in females, which might contribute to higher levels of immune activation and the observed faster HIV-1 disease progression in females for a given level of viral replication.

TL;DR: It is discussed how a better understanding of the underlying mechanisms could improve preventive and therapeutic strategies and how oestrogen receptor signalling could represent an important mediator of sex differences in HIV-1 reservoir size and may represent a potential therapeutic target.

TL;DR: Signaling via TLR7 leads to an upregulation of the transcription factor XBP1 in PBMCs and pDCs and is identified as a potential novel therapeutic target in IFN&agr;‐driven autoimmune and inflammatory diseases.