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Emily Stephenson
Researcher at Newcastle University
Publications - 31
Citations - 6828
Emily Stephenson is an academic researcher from Newcastle University. The author has contributed to research in topics: Immune system & Haematopoiesis. The author has an hindex of 12, co-authored 24 publications receiving 3842 citations.
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Journal ArticleDOI
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.
Alexandra-Chloé Villani,Alexandra-Chloé Villani,Rahul Satija,Rahul Satija,Gary Reynolds,Siranush Sarkizova,Karthik Shekhar,James Fletcher,Morgane Griesbeck,Andrew Butler,Shiwei Zheng,Suzan Lazo,Laura Jardine,David Dixon,Emily Stephenson,Emil Nilsson,Ida Grundberg,David McDonald,Andrew Filby,Weibo Li,Weibo Li,Philip L. De Jager,Philip L. De Jager,Orit Rozenblatt-Rosen,Andrew A. Lane,Andrew A. Lane,Muzlifah Haniffa,Muzlifah Haniffa,Aviv Regev,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +32 more
TL;DR: This refined analysis has identified, among others, a previously unknown dendritic cell population that potently activates T cells and reclassify pDCs as the originally described “natural interferon-producing cells (IPCs)” with weaker T cell proliferation induction ability.
Journal ArticleDOI
Single-cell reconstruction of the early maternal–fetal interface in humans
Roser Vento-Tormo,Roser Vento-Tormo,Mirjana Efremova,Rachel A. Botting,Margherita Y. Turco,Miquel Vento-Tormo,Kerstin B. Meyer,Jong-Eun Park,Emily Stephenson,Krzysztof Polanski,Angela Goncalves,Angela Goncalves,Lucy Gardner,Staffan Holmqvist,Johan Henriksson,Angela Zou,Andrew M. Sharkey,Ben Millar,Barbara A. Innes,Laura Wood,Anna Wilbrey-Clark,Rebecca Payne,Martin A. Ivarsson,Steve Lisgo,Andrew Filby,David H. Rowitch,Judith N. Bulmer,Gavin J. Wright,Michael J. T. Stubbington,Muzlifah Haniffa,Muzlifah Haniffa,Ashley Moffett,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann +34 more
TL;DR: A single-cell atlas of the maternal–fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success, and develops a repository of ligand–receptor complexes and a statistical tool to predict the cell–cell communication via these molecular interactions.
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Alexandra-Chloé Villani,Alexandra-Chloé Villani,Rahul Satija,Rahul Satija,Gary Reynolds,Siranush Sarkizova,Karthik Shekhar,James Fletcher,Morgane Griesbeck,Andrew Butler,Shiwei Zheng,Suzan Lazo,Laura Jardine,David Dixon,Emily Stephenson,Emil Nilsson,Ida Grundberg,David McDonald,Andrew Filby,Weibo Li,Weibo Li,Philip L. De Jager,Philip L. De Jager,Orit Rozenblatt-Rosen,Andrew A. Lane,Andrew A. Lane,Muzlifah Haniffa,Muzlifah Haniffa,Aviv Regev,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +32 more
TL;DR: In this paper, the authors performed single-cell RNA sequencing of ~2400 cells isolated from healthy blood donors and enriched for HLA-DR + lineage − cells, which led them to identify and validate six Dendritic cells (DCs) and four monocyte subtypes.
Journal ArticleDOI
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
Matthew D. Young,Thomas J. Mitchell,Thomas J. Mitchell,Thomas J. Mitchell,Felipe A. Vieira Braga,Maxine G. B. Tran,Benjamin J. Stewart,John R. Ferdinand,Grace Collord,Grace Collord,Grace Collord,Rachel A. Botting,Dorin-Mirel Popescu,Kevin W. Loudon,Roser Vento-Tormo,Emily Stephenson,Alex Cagan,Sarah J. Farndon,Sarah J. Farndon,Sarah J. Farndon,Martin Del Castillo Velasco-Herrera,Charlotte Guzzo,Nathan Richoz,Lira Mamanova,Tevita Aho,James N. Armitage,Antony C. P. Riddick,Imran Mushtaq,Stephen Farrell,Dyanne Rampling,James Nicholson,James Nicholson,Andrew Filby,Johanna Burge,Steven Lisgo,Patrick H. Maxwell,Susan Lindsay,Anne Y. Warren,Grant D. Stewart,Grant D. Stewart,Neil J. Sebire,Neil J. Sebire,Nicholas Coleman,Nicholas Coleman,Muzlifah Haniffa,Muzlifah Haniffa,Sarah A. Teichmann,Menna R. Clatworthy,Menna R. Clatworthy,Sam Behjati,Sam Behjati,Sam Behjati +51 more
TL;DR: It is determined that Wilms tumor, a pediatric kidney cancer, originates from aberrant fetal cells, whereas adult kidney cancers are likely derived from a specific subtype of proximal convoluted tubular cell.
Journal ArticleDOI
Decoding human fetal liver haematopoiesis
Dorin-Mirel Popescu,Rachel A. Botting,Emily Stephenson,Kile Green,Simone Webb,Laura Jardine,Emily Calderbank,Krzysztof Polanski,Issac Goh,Mirjana Efremova,Meghan Acres,Daniel Maunder,Peter Vegh,Yorick Gitton,Jong-Eun Park,Roser Vento-Tormo,Zhichao Miao,Zhichao Miao,David Dixon,Rachel Rowell,David McDonald,James Fletcher,Elizabeth Poyner,Gary Reynolds,Michael W. Mather,Corina Moldovan,Lira Mamanova,Frankie Greig,Matthew D. Young,Kerstin B. Meyer,Steven Lisgo,Jaume Bacardit,Andrew Fuller,Ben Millar,Barbara A. Innes,Susan Lindsay,Michael J. T. Stubbington,Monika S. Kowalczyk,Bo Li,Orr Ashenberg,Marcin Tabaka,Danielle Dionne,Timothy L. Tickle,Timothy L. Tickle,Michal Slyper,Orit Rozenblatt-Rosen,Andrew Filby,Peter D. Carey,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Anindita Roy,Aviv Regev,Aviv Regev,Alain Chédotal,Irene Roberts,Berthold Göttgens,Sam Behjati,Sam Behjati,Elisa Laurenti,Sarah A. Teichmann,Sarah A. Teichmann,Muzlifah Haniffa,Muzlifah Haniffa +62 more
TL;DR: A shift in the haemopoietic composition of fetal liver during gestation away from being predominantly erythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs is demonstrated, which is validated to produce an integrated map of fetal liver haematopoiesis.