M
Morgane Griesbeck
Researcher at Massachusetts Institute of Technology
Publications - 7
Citations - 2944
Morgane Griesbeck is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Viral load & Cytotoxic T cell. The author has an hindex of 6, co-authored 7 publications receiving 2168 citations.
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Journal ArticleDOI
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.
Alexandra-Chloé Villani,Alexandra-Chloé Villani,Rahul Satija,Rahul Satija,Gary Reynolds,Siranush Sarkizova,Karthik Shekhar,James Fletcher,Morgane Griesbeck,Andrew Butler,Shiwei Zheng,Suzan Lazo,Laura Jardine,David Dixon,Emily Stephenson,Emil Nilsson,Ida Grundberg,David McDonald,Andrew Filby,Weibo Li,Weibo Li,Philip L. De Jager,Philip L. De Jager,Orit Rozenblatt-Rosen,Andrew A. Lane,Andrew A. Lane,Muzlifah Haniffa,Muzlifah Haniffa,Aviv Regev,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +32 more
TL;DR: This refined analysis has identified, among others, a previously unknown dendritic cell population that potently activates T cells and reclassify pDCs as the originally described “natural interferon-producing cells (IPCs)” with weaker T cell proliferation induction ability.
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Alexandra-Chloé Villani,Alexandra-Chloé Villani,Rahul Satija,Rahul Satija,Gary Reynolds,Siranush Sarkizova,Karthik Shekhar,James Fletcher,Morgane Griesbeck,Andrew Butler,Shiwei Zheng,Suzan Lazo,Laura Jardine,David Dixon,Emily Stephenson,Emil Nilsson,Ida Grundberg,David McDonald,Andrew Filby,Weibo Li,Weibo Li,Philip L. De Jager,Philip L. De Jager,Orit Rozenblatt-Rosen,Andrew A. Lane,Andrew A. Lane,Muzlifah Haniffa,Muzlifah Haniffa,Aviv Regev,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen +32 more
TL;DR: In this paper, the authors performed single-cell RNA sequencing of ~2400 cells isolated from healthy blood donors and enriched for HLA-DR + lineage − cells, which led them to identify and validate six Dendritic cells (DCs) and four monocyte subtypes.
Journal ArticleDOI
Higher Expression of Several Interferon-Stimulated Genes in HIV-1-Infected Females After Adjusting for the Level of Viral Replication
J. Judy Chang,Matt Woods,Robert J. Lindsay,Erin Doyle,Morgane Griesbeck,Ellen S. Chan,Gregory K. Robbins,Ronald J. Bosch,Marcus Altfeld +8 more
TL;DR: Higher IFN-α production is associated with higher ex vivo expression of several ISGs in females, which might contribute to higher levels of immune activation and the observed faster HIV-1 disease progression in females for a given level of viral replication.
Journal ArticleDOI
Sex and gender differences in HIV-1 infection.
TL;DR: It is discussed how a better understanding of the underlying mechanisms could improve preventive and therapeutic strategies and how oestrogen receptor signalling could represent an important mediator of sex differences in HIV-1 reservoir size and may represent a potential therapeutic target.
Journal ArticleDOI
TLR7-mediated activation of XBP1 correlates with the IFNα production in humans.
Claudia Beisel,Susanne Ziegler,Glòria Martrus Zapater,Anais Chapel,Morgane Griesbeck,Heike Hildebrandt,Ansgar W. Lohse,Marcus Altfeld +7 more
TL;DR: Signaling via TLR7 leads to an upregulation of the transcription factor XBP1 in PBMCs and pDCs and is identified as a potential novel therapeutic target in IFN&agr;‐driven autoimmune and inflammatory diseases.