Myong In Oh

TL;DR: Furosemide is a reasonably potent inhibitor of IL-6 and TNF-α that is also safe, inexpensive and well-studied and suggests that it may be a candidate for repurposing as an inhaled therapy against COVID-19.

TL;DR: An information flow model is developed to evaluate the fluctuating nature of hydrogen bond networks and to characterise the dynamic, long-distance hydrogen-bonded chains in water and it is found that the length and directionality of the hydrogen bond "trails" are highly susceptible to the type of confining surfaces and the degree of confinement.

TL;DR: This study reveals that the effect of the aqueous interface on the first solvation shell of the ion pair and thus on the ion pairing thermodynamics becomes more pronounced in the polarizable model, and that the free energy profile along the interionic distance cannot capture the difference in the degree of solvent participation in ion pairing at the water/membrane interface.

TL;DR: Cholesterol provides a more bulk-like environment for the interfacial water molecules, as evidenced by enhancement of local water density, a reduction in their orientational bias, and increases in both the number of hydrogen bonds and the topological complexity of the hydrogen bond network.

TL;DR: In this paper, the anomalous behavior of water at the aqueous interface of a surface has been thoroughly investigated over the past decades, and indirect surface characterization based on the properties of i...