M
Myrto Samara
Researcher at Aristotle University of Thessaloniki
Publications - 60
Citations - 5647
Myrto Samara is an academic researcher from Aristotle University of Thessaloniki. The author has contributed to research in topics: Antipsychotic & Randomized controlled trial. The author has an hindex of 22, co-authored 51 publications receiving 4112 citations. Previous affiliations of Myrto Samara include University of Amsterdam & Technische Universität München.
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Journal ArticleDOI
Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis
Stefan Leucht,Andrea Cipriani,Andrea Cipriani,Loukia M. Spineli,Dimitris Mavridis,Deniz Örey,Franziska Richter,Myrto Samara,Corrado Barbui,Rolf R. Engel,John R. Geddes,Werner Kissling,Marko Paul Stapf,Bettina Lässig,Georgia Salanti,John M. Davis +15 more
TL;DR: A Bayesian-framework, multiple-treatments meta-analysis of randomised controlled trials to compare 15 antipsychotic drugs and placebo in the acute treatment of schizophrenia found all drugs were significantly more effective than placebo.
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Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis
Maximilian Huhn,Adriani Nikolakopoulou,Johannes Schneider-Thoma,Marc Krause,Myrto Samara,Natalie Peter,Thomas Arndt,Lio Bäckers,Philipp Rothe,Andrea Cipriani,John M. Davis,Georgia Salanti,Stefan Leucht +12 more
TL;DR: A network meta-analysis of placebo-controlled and head-to-head randomised controlled trials and compared 32 antipsychotics aimed to compare and rank antipsychotic drugs by quantifying information from randomisedcontrolled trials.
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Dose Equivalents for Antipsychotic Drugs: The DDD Method
TL;DR: It is recommended that if alternative, more "scientific" dose equivalence methods are available for a drug they should be preferred to DDDs, because the major limitations are that the information used to estimate DDDS is likely to differ between the drugs.
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Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors
Stefan Leucht,Claudia Leucht,Maximilian Huhn,Anna Chaimani,Dimitris Mavridis,Bartosz Helfer,Myrto Samara,Matteo Rabaioli,Susanne Bächer,Andrea Cipriani,John R. Geddes,Georgia Salanti,John M. Davis +12 more
TL;DR: Almost twice as many patients improved with antipsychotics as with placebo, but only a minority experienced a good response, and drug development may benefit from smaller samples but better-selected patients.
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Dose Equivalents for Second-Generation Antipsychotics: The Minimum Effective Dose Method
TL;DR: This method for determining antipsychotic dose equivalence entails an operationalized and evidence-based approach that can be applied to the various antipsychoses and is applicable to specific populations such as first-episode or refractory patients.