Myung Hee Chung

TL;DR: It is suggested that long-term exposure to the herbicide ATZ might contribute to the development of insulin resistance and obesity, particularly where a high-fat diet is prevalent.

TL;DR: DNA damage and attenuation of the damage by dietary restriction were assessed by measuring 8-hydroxydeoxyguanosine 8-OH dG) in both nuclear DNA (nuDNA) and mitochondrial DNA (mitDNA) fractions and it is shown that substantially more damage occurred in mitDNA compared to nuDNA and the DNA damage was significantly attenuated in dietarily restricted rats.

TL;DR: The novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative-stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced.

TL;DR: The findings show that measuring serum 8-OHG is a novel convenient method for evaluating oxidative DNA damage and suggests that such changes may contribute to the development of microvascular complications of diabetes.

TL;DR: Plasma 8-OHG levels in diabetic rats treated with insulin, insulin and probucol, or insulin and vitamin E and tissue 8- OHdG levels were significantly decreased by combined treatment with insulin and antioxidant (probucol or vitamin E), but not by insulin treatment alone, suggesting that plasma 8-ohG could be a useful biomarker of oxidative DNA damage in diabetic subjects.