Institution
Gachon University
Education•Seongnam-si, South Korea•
About: Gachon University is a education organization based out in Seongnam-si, South Korea. It is known for research contribution in the topics: Population & Medicine. The organization has 6390 authors who have published 13157 publications receiving 179763 citations.
Topics: Population, Medicine, Cancer, Apoptosis, Thin film
Papers published on a yearly basis
Papers
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TL;DR: The main goal of the HEVC standardization effort is to enable significantly improved compression performance relative to existing standards-in the range of 50% bit-rate reduction for equal perceptual video quality.
Abstract: High Efficiency Video Coding (HEVC) is currently being prepared as the newest video coding standard of the ITU-T Video Coding Experts Group and the ISO/IEC Moving Picture Experts Group. The main goal of the HEVC standardization effort is to enable significantly improved compression performance relative to existing standards-in the range of 50% bit-rate reduction for equal perceptual video quality. This paper provides an overview of the technical features and characteristics of the HEVC standard.
7,383 citations
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Wellcome Trust Sanger Institute1, Cambridge University Hospitals NHS Foundation Trust2, Lund University3, Erasmus University Medical Center4, Radboud University Nijmegen5, European Bioinformatics Institute6, University of Oslo7, Oslo University Hospital8, Gachon University9, Netherlands Cancer Institute10, Université libre de Bruxelles11, University of Antwerp12, Harvard University13, University of Amsterdam14, University of Ulsan15, Hanyang University16, Memorial Sloan Kettering Cancer Center17, University of Texas MD Anderson Cancer Center18, French Institute of Health and Medical Research19, Ninewells Hospital20, ICM Partners21, University of Queensland22, University of Iceland23, Curie Institute24, University of Cambridge25, King's College London26, Institute of Cancer Research27, University of Bergen28, Singapore General Hospital29
TL;DR: This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operative, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
Abstract: We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended to genome rearrangements and revealed twelve base substitution and six rearrangement signatures. Three rearrangement signatures, characterized by tandem duplications or deletions, appear associated with defective homologous-recombination-based DNA repair: one with deficient BRCA1 function, another with deficient BRCA1 or BRCA2 function, the cause of the third is unknown. This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operating, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
1,696 citations
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TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.
Abstract: Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1,2,3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10,11,12,13,14,15,16,17,18.
1,600 citations
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TL;DR: In this article, the formation of different types of oxygen containing functional groups in GO and their influences on its structure were analyzed using X-ray diffraction (XRD), Fourier transform infra-red spectra, x-ray photoelectron spectra (XPS), zeta potential analysis and Raman spectroscopy.
1,428 citations
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TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
1,271 citations
Authors
Showing all 6462 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ki-Hyun Kim | 99 | 1911 | 52157 |
Laurence A. Turka | 91 | 332 | 32347 |
Shmuel Muallem | 82 | 267 | 20869 |
Yangsoo Jang | 79 | 1072 | 29239 |
Jinwoo Lee | 77 | 458 | 21964 |
Young-Bum Kim | 70 | 447 | 22433 |
Seong-Jin Kim | 69 | 174 | 15049 |
Seung U. Kim | 64 | 355 | 14269 |
Chi-Chao Chan | 64 | 444 | 13867 |
Seung U. Kim | 63 | 129 | 11983 |
Eunyoung Cho | 58 | 284 | 12444 |
Donghoon Choi | 56 | 1015 | 17538 |
Ichiro Nakano | 53 | 168 | 10946 |
Jaehoon Lim | 52 | 308 | 10323 |
Senyon Choe | 52 | 127 | 9342 |