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N.H. Kulkarni
Researcher at Eli Lilly and Company
Publications - 13
Citations - 845
N.H. Kulkarni is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Parathyroid hormone & Ovariectomized rat. The author has an hindex of 10, co-authored 13 publications receiving 807 citations.
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Journal ArticleDOI
Effects of parathyroid hormone on Wnt signaling pathway in bone.
N.H. Kulkarni,David L. Halladay,Rebecca R. Miles,L.M. Gilbert,Charles A. Frolik,Rachelle J. Sells Galvin,Thomas J. Martin,Matthew T. Gillespie,Jude E. Onyia +8 more
TL;DR: The findings suggest that the effect of PTH on the canonical Wnt signaling pathway occurs at least in part via the cAMP‐PKA pathway through the differential regulation of the receptor complex proteins (FZD‐1/LRP5 or LRP6) and the antagonist (Dkk‐1).
Journal ArticleDOI
Orally Bioavailable GSK-3α/β Dual Inhibitor Increases Markers of Cellular Differentiation In Vitro and Bone Mass In Vivo
N.H. Kulkarni,Jude E. Onyia,Qingqiang Zeng,Xioayan Tian,Min Liu,David L. Halladay,Charles A. Frolik,Thomas A. Engler,Tao Wei,Aidas Kriauciunas,T. John Martin,Masahiko Sato,Henry Uhlman Bryant,Yanfei L. Ma +13 more
TL;DR: The effect of a small molecule GSK‐3 inhibitor was evaluated in pre‐osteoblasts and in osteopenic rats with concomitant increased bone mass and strength in rats.
Journal ArticleDOI
Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes
Jonathan H. Gooi,S. Pompolo,Morten A. Karsdal,N.H. Kulkarni,Ivo Kalajzic,S. H M McAhren,B. Han,Jude E. Onyia,P.W.M. Ho,Matthew T. Gillespie,Nicole C. Walsh,Ling Yeong Chia,J.M.W. Quinn,T. J. Martin,Natalie A. Sims +14 more
TL;DR: Co-treatment with sCT can blunt the anabolic effect of PTH and this may involve direct stimulation of sclerostin production by osteocytes, which directly implicate calcitonin as a negative regulator of bone formation through a previously unsuspected mechanism.
Journal ArticleDOI
Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: An analysis by DNA microarray
Jude E. Onyia,Leah M. Helvering,Lawrence M. Gelbert,Tao Wei,Shuguang Huang,Peining Chen,Ernst R. Dow,Avudaiappan Maran,M. Zhang,Sutada Lotinun,Xi Lin,David L. Halladay,Rebecca R. Miles,N.H. Kulkarni,Emily M. Ambrose,Yanfei L. Ma,Charles A. Frolik,Masahiko Sato,Henry Uhlman Bryant,Russell T. Turner +19 more
TL;DR: The broad profiling of the gene and pathway changes that occur in vivo following treatment of intermittent versus continuous PTH is detailed for the first time and the in vivo regulation of BMP3 and multiple neuronal genes by PTH treatment is revealed.
Journal ArticleDOI
Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage
Tao Wei,N.H. Kulkarni,Qingqiang Zeng,Leah M. Helvering,Xi Lin,Frank Lawrence,Laura V. Hale,Mark Chambers,C. Lin,Anita K. Harvey,Yanfei L. Ma,R.L. Cain,J.L. Oskins,M.A. Carozza,D.D. Edmondson,T. Hu,Rebecca R. Miles,T.P. Ryan,Jude E. Onyia,P.G. Mitchell +19 more
TL;DR: While there was lack of overall identity in cartilage gene expression between the rat models and human OA, several key biological processes were recapitulated in the rat MT OA model.