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Nadia Cervoni
Researcher at McGill University
Publications - 8
Citations - 7191
Nadia Cervoni is an academic researcher from McGill University. The author has contributed to research in topics: DNA demethylation & DNA methylation. The author has an hindex of 8, co-authored 8 publications receiving 6833 citations.
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Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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A mammalian protein with specific demethylase activity for mCpG DNA
TL;DR: The discovery of this DNA demethylase should provide a basis for the molecular and developmental analysis of the role of DNA methylation and demethylation.
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DNA methylation is a reversible biological signal
TL;DR: It is shown that similar to DNA methyltransferase, DNA demethylase shows CpG dinucleotide specificity, can demethylate mdCpdG sites in different sequence contexts, and demethylates both fully methylated and hemimethylated DNA.
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Demethylase activity is directed by histone acetylation
Nadia Cervoni,Moshe Szyf +1 more
TL;DR: It is shown here using a transient transfection model that an active demethylase is involved in shaping patterns of methylation in somatic cells and this provides a simple mechanism for explaining why active genes are not methylated.
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The Oncoprotein Set/TAF-1β, an Inhibitor of Histone Acetyltransferase, Inhibits Active Demethylation of DNA, Integrating DNA Methylation and Transcriptional Silencing
TL;DR: It is shown that the overexpression of Set/TAF-Iβ, whose expression is up-regulated in multiple tumor tissues, inhibits demethylation of ectopically methylated DNA resulting in gene silencing and provides a new mechanism that can explain how hypermethylation of specific regions might come about by inhibition of dem methylation in cancer cells.