N
Nambirajan Govindarajan
Researcher at University of Göttingen
Publications - 3
Citations - 685
Nambirajan Govindarajan is an academic researcher from University of Göttingen. The author has contributed to research in topics: Histone deacetylase & Fear processing in the brain. The author has an hindex of 3, co-authored 3 publications receiving 566 citations.
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Journal ArticleDOI
Sodium Butyrate Improves Memory Function in an Alzheimer's Disease Mouse Model When Administered at an Advanced Stage of Disease Progression
Nambirajan Govindarajan,Roberto Carlos Agis-Balboa,Jonas Walter,Farahnaz Sananbenesi,Andre Fischer +4 more
TL;DR: It is shown that severe amyloid pathology correlates with a pronounced dysregulation of histone acetylation in the forebrain of APPPS1-21 mice, and prolonged treatment with the pan-HDAC inhibitor sodium butyrate improved associative memory in APPPS 1- 21 mice even when administered at a very advanced stage of pathology.
Journal ArticleDOI
Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease.
Nambirajan Govindarajan,Pooja Rao,Susanne Burkhardt,Susanne Burkhardt,Farahnaz Sananbenesi,Farahnaz Sananbenesi,Oliver M. Schlüter,Frank Bradke,Jianrong Lu,Andre Fischer,Andre Fischer +10 more
TL;DR: It is reported that mice lacking HDAC6 are cognitively normal but reducing endogenousHDAC6 levels restores learning and memory and α‐tubulin acetylation in a mouse model for Alzheimer's disease (AD).
Journal ArticleDOI
A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories.
Roberto Carlos Agis-Balboa,Dario Arcos-Diaz,Jessica Wittnam,Nambirajan Govindarajan,Kim Blom,Susanne Burkhardt,Ulla Haladyniak,Hope Y Agbemenyah,Athanasios Zovoilis,Gabriella Salinas-Riester,Lennart Opitz,Farahnaz Sananbenesi,Andre Fischer,Andre Fischer +13 more
TL;DR: It is demonstrated that therapeutic strategies that enhance IGF2 signalling and adult neurogenesis might be suitable to treat disease linked to excessive fear memory, and that fear extinction‐induced IGF2/IGFBP7 signalling promotes the survival of 17–19‐day‐old newborn hippocampal neurons.