S
Susanne Burkhardt
Researcher at German Center for Neurodegenerative Diseases
Publications - 35
Citations - 3527
Susanne Burkhardt is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Gonyaulax & Histone. The author has an hindex of 21, co-authored 32 publications receiving 3007 citations. Previous affiliations of Susanne Burkhardt include University of Texas Health Science Center at San Antonio & University of Göttingen.
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Journal ArticleDOI
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Shahaf Peleg,Farahnaz Sananbenesi,Athanasios Zovoilis,Susanne Burkhardt,Sanaz Bahari-Javan,Roberto Carlos Agis-Balboa,Perla Cota,Jessica Wittnam,Andreas Gogol-Doering,Lennart Opitz,Gabriella Salinas-Riester,Markus Dettenhofer,Hui Kang,Laurent Farinelli,Wei Chen,Andre Fischer +15 more
TL;DR: It is shown that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity, and data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the Aging mouse brain.
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microRNA‐34c is a novel target to treat dementias
Athanasios Zovoilis,Hope Y Agbemenyah,Roberto Carlos Agis-Balboa,Roman M. Stilling,Dieter Edbauer,Pooja Rao,Laurent Farinelli,Ivana Delalle,Andrea Schmitt,Andrea Schmitt,Peter Falkai,Peter Falkai,Sanaz Bahari-Javan,Susanne Burkhardt,Farahnaz Sananbenesi,Andre Fischer,Andre Fischer +16 more
TL;DR: The data suggest that miR‐34c could be a marker for the onset of cognitive disturbances linked to AD and indicate that targeting miR-34ccould be a suitable therapy.
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DNA methylation changes in plasticity genes accompany the formation and maintenance of memory
Rashi Halder,Magali Hennion,Ramon O. Vidal,Orr Shomroni,Raza-Ur Rahman,Ashish Rajput,Tonatiuh Pena Centeno,Frauke van Bebber,Vincenzo Capece,Julio C. Garcia Vizcaino,Anna-Lena Schuetz,Susanne Burkhardt,Eva Benito,Magdalena Navarro Sala,Sanaz Bahari Javan,Christian Haass,Bettina Schmid,Andre Fischer,Andre Fischer,Stefan Bonn +19 more
TL;DR: It is found that histone modifications predominantly changed during memory acquisition and correlated surprisingly little with changes in gene expression, providing evidence for a molecular framework ofMemory acquisition and maintenance, wherein DNA methylation could alter the expression and splicing of genes involved in functional plasticity and synaptic wiring.
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Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease.
Nambirajan Govindarajan,Pooja Rao,Susanne Burkhardt,Susanne Burkhardt,Farahnaz Sananbenesi,Farahnaz Sananbenesi,Oliver M. Schlüter,Frank Bradke,Jianrong Lu,Andre Fischer,Andre Fischer +10 more
TL;DR: It is reported that mice lacking HDAC6 are cognitively normal but reducing endogenousHDAC6 levels restores learning and memory and α‐tubulin acetylation in a mouse model for Alzheimer's disease (AD).
Journal ArticleDOI
Melatonin's unique radical scavenging properties – roles of its functional substituents as revealed by a comparison with its structural analogs
Burkhard Poeggeler,Sandra Thuermann,Andreas Dose,Markus Schoenke,Susanne Burkhardt,Rüdiger Hardeland +5 more
TL;DR: Melatonin's redox chemistry is compared with that of several structural analogs, indicating that radical chain termination by O2·− is considerably more efficient with melatonin, which was much more rapidly oxidized than the 5‐hydroxylated and non‐substituted analogs.