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Nancy J. Boerth
Researcher at University of Alabama at Birmingham
Publications - 11
Citations - 1157
Nancy J. Boerth is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Protein kinase A & Vascular smooth muscle. The author has an hindex of 10, co-authored 11 publications receiving 1139 citations.
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Journal ArticleDOI
Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP
TL;DR: It is suggested that cGMP-dependent activation of the cAMP kinase may be responsible in part at least for the NO-dependent inhibition of proliferation of subcultured rat aortic SMC.
Journal ArticleDOI
Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype.
TL;DR: It is suggested that PKG expression contributes to the regulation of a contractile-like phenotypic expression in cultured VSMC, and the suppression of PKGexpression during cultured growth in vitro may permit the modulation of cells to a more synthetic, dedifferentiated phenotype.
Book ChapterDOI
cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases
Thomas M. Lincoln,Padmini Komalavilas,Nancy J. Boerth,Lee Ann MacMillan-Crow,Trudy L. Cornwell +4 more
TL;DR: The signaling pathways by which nitric oxide affects cell function, are by no means limited to the stimulation of guanylate cyclase, and one of the recently described mechanisms of NO signaling, at least in terms of its pathophysiological effects on cells, is the formation of peroxynitrite.
Journal ArticleDOI
Cyclic GMP–Dependent Protein Kinase Expression in Coronary Arterial Smooth Muscle in Response to Balloon Catheter Injury
Peter G. Anderson,Nancy J. Boerth,Ming Liu,Dennis B. McNamara,Trudy L. Cornwell,Thomas M. Lincoln +5 more
TL;DR: The results suggest that PKG expression is transiently reduced in response to injury in the population of coronary arterial smooth muscle cells that are actively proliferating and producing extracellular matrix proteins.
Journal ArticleDOI
Nitric oxide - cyclic GMP pathway regulates vascular smooth muscle cell phenotypic modulation : implications in vascular diseases
TL;DR: It is suggested that PKG occupies a critical role in VSMC phenotype and that suppression of PKG expression during inflammation or injury promotes a more synthetic state of the VSMC.