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Nancy L. Earl
Researcher at Research Triangle Park
Publications - 4
Citations - 357
Nancy L. Earl is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Ropinirole & Randomized controlled trial. The author has an hindex of 4, co-authored 4 publications receiving 344 citations.
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Journal ArticleDOI
Sudden Unexplained Death in Epilepsy: Observations from a Large Clinical Development Program
Jan E. Leestma,John F. Annegers,Martin J. Brodie,Stephen Brown,Paul L. Schraeder,David S. Siscovick,Braxton B. Wannamaker,Patricia Tennis,Mark A. Cierpial,Nancy L. Earl +9 more
TL;DR: The rate of sudden unexplained death in epilepsy (SUDEP) in a well‐defined cohort of patients included in the lamotrigine (LTG) clinical development database was determined.
Journal ArticleDOI
Onset of dyskinesia with adjunct ropinirole prolonged-release or additional levodopa in early Parkinson's disease.
Ray L. Watts,Kelly E. Lyons,Rajesh Pahwa,Kapil D. Sethi,Matthew B. Stern,Robert A. Hauser,Warren Olanow,Alex M. Gray,Bryan Adams,Nancy L. Earl +9 more
TL;DR: Ropinirole prolonged‐release delayed the onset of dyskinesia with comparable efficacy to increased doses of levodopa in early PD patients not optimally controlled with levodOPA, suggesting comparable efficacy between the two treatments.
Journal ArticleDOI
Early treatment benefits of ropinirole prolonged release in Parkinson's disease patients with motor fluctuations.
TL;DR: It is indicated that once‐daily, adjunctive ropinirole prolonged release can offer PD symptom control 2 weeks after treatment initiation, and the cardinal symptoms of PD compared with placebo.
Journal ArticleDOI
Clinical Safety of 311C90: Aggregated Data from Patients and Volunteers to Date
TL;DR: The tolerability of 311C90, a novel, selective and highly effective 5-HT1D receptor agonist in development for the acute treatment of migraine, has been well tolerated across the entire dose range and no clinically relevant changes in routine laboratory parameters, blood pressure or ECG recordings have been observed.