N
Naoki Yoshimura
Researcher at University of Pittsburgh
Publications - 509
Citations - 14831
Naoki Yoshimura is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Urinary bladder & Cystometry. The author has an hindex of 65, co-authored 483 publications receiving 13397 citations. Previous affiliations of Naoki Yoshimura include Kyoto University & Tokyo Medical and Dental University.
Papers
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Neural Control of the Lower Urinary Tract
TL;DR: This article summarizes anatomical, neurophysiological, pharmacological, and brain imaging studies in humans and animals that have provided insights into the neural circuitry and neurotransmitter mechanisms controlling the lower urinary tract.
Journal ArticleDOI
Increased Excitability of Afferent Neurons Innervating Rat Urinary Bladder after Chronic Bladder Inflammation
Naoki Yoshimura,W.C. de Groat +1 more
TL;DR: It is suggested that chronic inflammation induces somal hypertrophy and increases the excitability of C-fiber bladder afferent neurons by suppressing IA channels and similar electrical changes in sensory pathways may contribute to cystitis-induced pain and hyperactivity of the bladder.
Journal ArticleDOI
Pharmacology of the Lower Urinary Tract
TL;DR: This chapter will review recent advances in the understanding of the pathophysiology of voiding disorders and the targets for drug therapy.
Book ChapterDOI
Afferent nerve regulation of bladder function in health and disease.
TL;DR: The afferent innervation of the urinary bladder consists primarily of small myelinated and unmyelinated axons that respond to chemical and mechanical stimuli, which alter the chemical and electrical properties of bladder afferent pathways, leading to urinary urgency, increased voiding frequency, nocturia, urinary incontinence and pain.
Journal ArticleDOI
Cool (trpm8) and hot (trpv1) receptors in the bladder and male genital tract
Robert J. Stein,Soledad Santos,Jiro Nagatomi,Yukio Hayashi,Brandon S. Minnery,Macrina Xavier,Ankur S. Patel,Joel B. Nelson,William J. Futrell,Naoki Yoshimura,Michael B. Chancellor,Fernando De Miguel +11 more
TL;DR: Results demonstrate that mRNA and protein for TRPM8 exist in multiple genitourinary organs in the rat and human, and it may be considered a possible new target, as is TRPV1, for the pharmacological treatment of detrusor overactivity or other urological disorders.