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Naoko Arai
Researcher at Osaka Bioscience Institute
Publications - 12
Citations - 1609
Naoko Arai is an academic researcher from Osaka Bioscience Institute. The author has contributed to research in topics: Gene & T cell. The author has an hindex of 8, co-authored 12 publications receiving 1598 citations.
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Journal Article
Expression of the Fas ligand in cells of T cell lineage.
Takashi Suda,Takahiro Okazaki,Yoshiyuki Naito,Takashi Yokota,Naoko Arai,Shoichi Ozaki,Kazuwa Nakao,Shigekazu Nagata +7 more
TL;DR: Among tissues, lymphoid organs (thymus, lymph node, spleen), lung, and small intestine express low levels of FasL mRNA, suggesting the role of Fas L in the general immune system and mucosal immunity, and distribution of Fasl mRNA in a panel of cell lines indicated that the FasL expression is rather restricted to the cells of T cell lineage.
Journal Article
Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells.
J W Lowenthal,B E Castle,J Christiansen,Jolanda Schreurs,D. Rennick,Naoko Arai,P. Hoy,Yutaka Takebe,M Howard +8 more
TL;DR: It is shown on the basis of several criteria thatIL-4 retains full biologic activity after radioiodination and can therefore be used as a valid model for measuring the binding characteristics of native IL-4.
Journal Article
B cell growth-promoting activity of recombinant human interleukin 4.
Thierry Defrance,Béatrice Vanbervliet,J P Aubry,Y Takebe,Naoko Arai,Atsushi Miyajima,Takashi Yokota,Frank D. Lee,Ken-ichi Arai,J E de Vries +9 more
TL;DR: It was found that interferon-gamma enhanced the IL-4-induced proliferation of anti-IgM-preactivated B cells, andIL-4 is able to induce the proliferation of an appropriately activated subpopulation of human B cells.
Journal ArticleDOI
Coordinate regulation of immune and inflammatory responses by T cell-derived lymphokines.
Atsushi Miyajima,S Miyatake,J. Schreurs,J. E. De Vries,Naoko Arai,Takashi Yokota,Ken-ichi Arai +6 more
TL;DR: In response to antigenic stimulation, helper T cells secrete a set of protein mediators called lymphokines that regulate proliferation, differentiation, and maturation of lymphocytes and hemopoietic cells.
Journal Article
Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.
Naoko Arai,D Nomura,D Villaret,R DeWaal Malefijt,Motoharu Seiki,Mitsuaki Yoshida,S. Minoshima,R. Fukuyama,M. Maekawa,J Kudoh +9 more
TL;DR: The 2.3-kb 5'-flanking region of the human IL-4 gene transiently transfected into Jurkat human T cell leukemia cells is activated efficiently in response to TPA and A23187 stimulation and, although less efficiently, by human Tcell leukemia virus type I-encoded p40x or BPV-encoding E2 protein.