Béatrice Vanbervliet

TL;DR: The observation that CCR6 mRNA expression decreases progressively as DCs mature, whereas CCR7 mRNA expression is sharply upregulated, provides a likely explanation for the changes in chemokine responsiveness, and suggests a role for MIP-3α/CCR6 in recruitment of immature DCs at site of injury and for Mip-3β/CCr7 in accumulation of antigen-loaded mature DCs in T cell–rich areas.

TL;DR: It is demonstrated that dendritic Langerhans cells (D-Lc) generated by culturing cord blood CD34+ progenitor cells with granulocyte/macrophage colony-stimulating and tumor necrosis factor alpha (TNF-alpha) express functional CD40 at a density higher than that found on B cells.

TL;DR: The present study demonstrates that cord blood CD34+ HPC indeed differentiate along two independent DC pathways, and demonstrates that different pathways of DC development exist: the Langerhans cells and the CD14(+)-derived DC related to dermal DC or circulating blood DC.

TL;DR: The data suggest that TGF-beta is involved in the regulation of IgA isotype selection in humans, and that the B cell populations positively selected on the basis of sIgD expression were highly enriched for naive B lymphocytes.

TL;DR: The pattern of cytokines expressed by two independent dendritic cell (DC) subpopulations generated in vitro from human cord blood CD34+ progenitors cultured with granulocyte-macrophage CSF and TNF-alpha seemed more closely related to germinal center d endritic cellsGCDC than to Langerhans cells.