Polymer microspheres for controlled drug release

Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles.

Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo.

Controlled drug delivery technology is concerned with the systematic release of a pharmaceutical agent to maintain a therapeutic level of the drug in the body for a sustained period of time. This may be achieved by incorporating the therapeutic agent into a degradable polymer vehicle, releasing the agent continuously as the matrix erodes. This review is concerned with degradable polymers for use in controlled drug delivery with emphasis on the preparation, applications, biocompatibility, and stability of microspheres from hydrolytically degradable polymers.

Degradable polymer microspheres for controlled drug delivery

Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery

Pulsatile drug release from poly (lactide-co-glycolide) microspheres: how does the composition of the polymer matrices affect the time interval between the initial burst and the pulsatile release of drugs?

Naoko Ohtake

Papers

Pulsatile drug release from poly (lactide-co-glycolide) microspheres: how does the composition of the polymer matrices affect the time interval between the initial burst and the pulsatile release of drugs?

Sustained release of 17β-estradiol from poly (lactide-co-glycolide) microspheres in vitro and in vivo