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Naomi M. Simon
Researcher at Harvard University
Publications - 5
Citations - 882
Naomi M. Simon is an academic researcher from Harvard University. The author has contributed to research in topics: Major depressive disorder & Interleukin 6. The author has an hindex of 5, co-authored 5 publications receiving 817 citations. Previous affiliations of Naomi M. Simon include New York University.
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Journal ArticleDOI
Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging.
Naomi M. Simon,Jordan W. Smoller,Kate McNamara,Richard S. Maser,Alyson K. Zalta,Mark H. Pollack,Andrew A. Nierenberg,Maurizio Fava,Kwok-Kin Wong +8 more
TL;DR: Preliminary evidence that mood disorders are associated with accelerated aging is provided and a novel mechanism for mood disorder-associated morbidity and mortality is suggested.
Journal ArticleDOI
A Detailed Examination of Cytokine Abnormalities in Major Depressive Disorder
Naomi M. Simon,Kate McNamara,Candice W. Chow,Richard S. Maser,George I. Papakostas,Mark H. Pollack,Andrew A. Nierenberg,Maurizio Fava,Kwok-Kin Wong +8 more
TL;DR: Data support a generalized chronic inflammatory state in MDD, and implicate additional cytokines and chemokines previously linked to cardiovascular disease.
Journal ArticleDOI
Inflammatory cytokines in major depressive disorder: A case–control study:
Paolo Cassano,Eric Bui,Andrew H. Rogers,Zandra E. Walton,Rachel A. Ross,Mary Zeng,Mireya Nadal-Vicens,David Mischoulon,Amanda W. Baker,Aparna Keshaviah,John J. Worthington,Elizabeth A. Hoge,Jonathan E. Alpert,Maurizio Fava,Kwok K. Wong,Naomi M. Simon +15 more
TL;DR: The heterogeneity of major depressive disorder, as well as a potential sampling bias selecting for non-inflammatory depression, might have determined the findings discordant with the literature.
Journal ArticleDOI
Telomere length and telomerase in a well-characterized sample of individuals with major depressive disorder compared to controls.
Naomi M. Simon,Zandra E. Walton,Eric Bui,Jennifer Prescott,Elizabeth A. Hoge,Aparna Keshaviah,Noah Schwarz,Taylor Dryman,Rebecca A. Ojserkis,Benjamin Kovachy,David Mischoulon,John J. Worthington,Immaculata DeVivo,Immaculata DeVivo,Maurizio Fava,Kwok-Kin Wong +15 more
TL;DR: A well-characterized, well-powered examination of concurrently assessed telomere length and telomerase activity in individuals with clinically significant, chronic MDD and matched controls failed to provide strong evidence of an association of MDD with shorter LTL, while telomersase activity was higher in men with MDD.
Journal ArticleDOI
Prospective association between major depressive disorder and leukocyte telomere length over two years.
Mary C. Vance,Eric Bui,Susanne S. Hoeppner,Benjamin Kovachy,Jennifer Prescott,David Mischoulon,Zandra E. Walton,Melissa Dong,Mireya Nadal,John J. Worthington,Elizabeth A. Hoge,Paolo Cassano,Esther H. Orr,Maurizio Fava,Immaculata De Vivo,Kwok-Kin Wong,Naomi M. Simon +16 more
TL;DR: A baseline diagnosis of MDD prospectively predicted LTL shortening over two years, providing further support for MDD as a disease associated with accelerated aging in a well-characterized sample using validated, clinician-rated measures.