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Narcis I. Popescu
Researcher at Oklahoma Medical Research Foundation
Publications - 28
Citations - 1224
Narcis I. Popescu is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Sepsis & Complement system. The author has an hindex of 11, co-authored 25 publications receiving 979 citations.
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Journal ArticleDOI
Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan
Andrea J. Wolf,Christopher N. Reyes,Wenbin Liang,Courtney A. Becker,Kenichi Shimada,Matthew L. Wheeler,Hee Cheol Cho,Narcis I. Popescu,K. Mark Coggeshall,Moshe Arditi,David M. Underhill +10 more
TL;DR: This study shows that a metabolic enzyme can act as a pattern recognition receptor and is caused by release of N-acetylglucosamine that is detected in the cytosol by the glycolytic enzyme hexokinase.
Journal ArticleDOI
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis
Robert Silasi-Mansat,Hua Zhu,Narcis I. Popescu,G. Peer,Georgia Sfyroera,Paola Magotti,Lacramioara Ivanciu,Cristina Lupu,Tom Eirik Mollnes,Tom Eirik Mollnes,Fletcher B. Taylor,Gary T. Kinasewitz,John D. Lambris,Florea Lupu +13 more
TL;DR: It is concluded that complement-coagulation interplay contributes to the progression of severe sepsis and blocking the harmful effects of complement activation products, especially during the organ failure stage of severe Sepsis is a potentially important therapeutic strategy.
Journal ArticleDOI
MicroRNA-19 (miR-19) Regulates Tissue Factor Expression in Breast Cancer Cells
Xiaoxi Zhang,Haijun Yu,Jessica R. Lou,Jie Zheng,Hua Zhu,Narcis I. Popescu,Florea Lupu,Stuart E. Lind,Wei Qun Ding +8 more
TL;DR: It is demonstrated that microRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells, providing a molecular basis for the selective expression of the tissue factor gene.
Journal ArticleDOI
Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure.
TL;DR: A new mechanism for PDI contribution to coagulation on endothelial cells is identified, namely, the regulation of PS exposure, where PDI acts as a negative regulator of coagulations.
Journal ArticleDOI
Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor.
Haiwang Tang,Lacramioara Ivanciu,Narcis I. Popescu,G. Peer,Erik Hack,Cristina Lupu,Fletcher B. Taylor,Fletcher B. Taylor,Florea Lupu,Florea Lupu +9 more
TL;DR: It is concluded that activation of TF-driven coagulation not adequately countered by TFPI may underlie the widespread thrombotic complications of sepsis.