N
Nariman F. Salakhutdinov
Researcher at Russian Academy of Sciences
Publications - 394
Citations - 4121
Nariman F. Salakhutdinov is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 27, co-authored 340 publications receiving 3036 citations. Previous affiliations of Nariman F. Salakhutdinov include Novosibirsk State University.
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Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor
Nadezhda S Dyrkheeva,A.A. Malakhova,Alexandra L. Zakharenko,Larisa S. Okorokova,Dmitriy N. Shtokalo,S. V. Pavlova,Sergey P. Medvedev,Suren M. Zakian,Anna A. Nushtaeva,Alexey E. Tupikin,Marsel R. Kabilov,Svetlana N. Khodyreva,Olga A. Luzina,Nariman F. Salakhutdinov,Olga I. Lavrik +14 more
TL;DR: In this paper , the authors performed a transcriptomic analysis of wild type and PARP1 knockout HEK293A cells treated with topotecan and TDP1 inhibitor OL9-119 alone and in combination.
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Chemical Modification of Usnic Acid. Part 2. Reactions of (+)-Usnic Acid with Amino Acids.
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The main protease 3CLpro of the SARS-CoV-2 virus: how to turn an enemy into a helper
S. V. Belenkaya,Iuliia Merkuleva,Olga I. Yarovaya,V.Yu. Chirkova,Elena Sharlaeva,Daniil V. Shanshin,Ekaterina A Volosnikova,Sergey Z. Vatsadze,M. V. Khvostov,Nariman F. Salakhutdinov,D. N. Shcherbakov +10 more
TL;DR: In this paper , the main viral protease 3CL of the SARS-CoV-2 virus was used to obtain a recombinant 3CL protease and studied its complex catalytic properties.
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Development of an LC-MS/MS-based method for quantification and pharmacokinetics study on SCID mice of a dehydroabietylamine-adamantylamine conjugate, a promising inhibitor of the DNA repair enzyme.
Alina A. Okhina,Artem D. Rogachev,Kseniya S. Kovaleva,Olga I. Yarovaya,Anna S. Khotskina,Evgeniy L. Zavyalov,Sergey Z. Vatsadze,Andrey G. Pokrovsky,Nariman F. Salakhutdinov +8 more
TL;DR: In this paper , the authors developed a method for quantification of Tdp1 inhibitor based on dehydroabietylamine and 1-aminoadamantane in mice.
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New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan
T. M. Khomenko,Alexandra L. Zakharenko,Tatyana E Kornienko,Arina A Chepanova,Nadezhda S Dyrkheeva,Dina V. Korchagina,Chigozie Achara,Jóhannes Reynisson,Konstantin P. Volcho,Nariman F. Salakhutdinov,Olga I. Lavrik +10 more
TL;DR: In this paper , a set of new 5-hydroxycoumarin derivatives containing monoterpene moieties was synthesized, and most of the conjugates demonstrated high inhibitory properties against TDP1 with an IC50 in low micromolar or nanomolar ranges.