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Natalia Fernandez
Researcher at Hebron University
Publications - 1
Citations - 133
Natalia Fernandez is an academic researcher from Hebron University. The author has contributed to research in topics: Cancer & Wnt signaling pathway. The author has an hindex of 1, co-authored 1 publications receiving 114 citations.
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Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer
Oriol Arqués,Irene Chicote,Isabel Puig,Stephan P. Tenbaum,Guillem Argiles,Rodrigo Dienstmann,Rodrigo Dienstmann,Natalia Fernandez,Ginevra Caratu,Judit Matito,Daniel Silberschmidt,Jordi Rodon,Stefania Landolfi,Aleix Prat,Eloy Espin,Ramón Charco,Paolo Nuciforo,Ana Vivancos,Wenlin Shao,Josep Tabernero,Hector G. Palmer +20 more
TL;DR: Investigation of Wnt-mediated resistance in patients treated with PI3K or AKT inhibitors in clinical trials and evaluation of the efficacy of a new Wnt/tankyrase inhibitor, NVP-TNKS656, to overcome such resistance finds high nuclear β-catenin content independently predicts resistance to PI3k and AKT inhibitor-resistant cells.