N
Natalia Lozovaya
Researcher at Aix-Marseille University
Publications - 32
Citations - 1927
Natalia Lozovaya is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: GABAergic & Epilepsy. The author has an hindex of 17, co-authored 31 publications receiving 1645 citations. Previous affiliations of Natalia Lozovaya include French Institute of Health and Medical Research.
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Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring.
Roman Tyzio,Roman Tyzio,Romain Nardou,Diana C. Ferrari,Timur Tsintsadze,Timur Tsintsadze,Amene Shahrokhi,Sanaz Eftekhari,Ilgam Khalilov,Ilgam Khalilov,Vera Tsintsadze,Vera Tsintsadze,Corinne Brouchoud,Corinne Brouchoud,Geneviève Chazal,Geneviève Chazal,Eric Lemonnier,Natalia Lozovaya,Natalia Lozovaya,Nail Burnashev,Nail Burnashev,Yehezkel Ben-Ari,Yehezkel Ben-Ari +22 more
TL;DR: The data validate the amelioration observed with bumetanide and oxytocin and point to common pathways in a drug-induced and a genetic rodent model of autism.
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GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction.
Gaetan Lesca,Gabrielle Rudolf,Nadine Bruneau,Natalia Lozovaya,Audrey Labalme,Nadia Boutry-Kryza,Manal Salmi,Timur Tsintsadze,Laura Addis,Jacques Motte,Sukhvir Wright,Vera Tsintsadze,Vera Tsintsadze,Vera Tsintsadze,Anne Michel,Diane Doummar,Karine Lascelles,Lisa J. Strug,Patrick Waters,Julitta de Bellescize,Pascal Vrielynck,Anne de Saint Martin,Dorothée Ville,Philippe Ryvlin,Alexis Arzimanoglou,Edouard Hirsch,Angela Vincent,Deb K. Pal,Nail Burnashev,Damien Sanlaville,Pierre Szepetowski +30 more
TL;DR: It is demonstrated that about 20% of cases of LKS, CSWSS and electroclinically atypical rolandic epilepsy often associated with speech impairment can have a genetic origin sustained by de novo or inherited mutations in the GRIN2A gene (encoding the N-methyl-D-aspartate (NMDA) glutamate receptor α2 subunit, GluN2A).
Journal ArticleDOI
GRIN2A mutations cause epilepsy-aphasia spectrum disorders
Gemma L. Carvill,Brigid M. Regan,Simone C. Yendle,Brian J. O'Roak,Natalia Lozovaya,Nadine Bruneau,Nail Burnashev,Adiba Khan,Joseph Cook,Eileen Geraghty,Lynette G. Sadleir,Samantha J. Turner,Meng-Han Tsai,Richard Webster,Robert A. Ouvrier,John A. Damiano,Samuel F. Berkovic,Jay Shendure,Michael S. Hildebrand,Pierre Szepetowski,Ingrid E. Scheffer,Ingrid E. Scheffer,Heather C Mefford +22 more
TL;DR: The first monogenic cause, to the authors' knowledge, for EAS is reported and GRIN2A mutations are restricted to this group of cases, which has important ramifications for diagnostic testing and treatment and provides new insights into the pathogenesis of this debilitating group of conditions.
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Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.
Natalia Lozovaya,S. Gataullina,Timur Tsintsadze,Vera Tsintsadze,Emilie Pallesi-Pocachard,Marat Minlebaev,Natalia A. Goriounova,Emmanuelle Buhler,Françoise Watrin,Sergey Shityakov,Albert J. Becker,Angélique Bordey,Mathieu Milh,D. Scavarda,Christine Bulteau,Georges Dorfmüller,Olivier Delalande,Alfonso Represa,Carlos Cardoso,Olivier Dulac,Yehezkel Ben-Ari,Nail Burnashev +21 more
TL;DR: It is reported that tuberless heterozygote Tsc1+/− mice show functional upregulation of cortical GluN2C-containing N-methyl-D-aspartate receptors (NMDARs) in an mTOR-dependent manner and exhibit recurrent, unprovoked seizures during early postnatal life, which constitutes a promising molecular target to treat epilepsy in TSC patients.
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Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids
TL;DR: It is demonstrated that cannabinoids may directly affect the functioning of inhibitory glycine receptor (GlyR) channels and that the direct inhibition of GlyRs by endocannabinoids can modulate the hippocampal network activity.