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Natalia V. Belosludtseva
Researcher at Russian Academy of Sciences
Publications - 68
Citations - 768
Natalia V. Belosludtseva is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Mitochondrion & Mitochondrial permeability transition pore. The author has an hindex of 12, co-authored 57 publications receiving 494 citations. Previous affiliations of Natalia V. Belosludtseva include Mari State University.
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Journal ArticleDOI
Mitochondrial Ca2+ Transport: Mechanisms, Molecular Structures, and Role in Cells.
TL;DR: The pathophysiological mechanism of Ca2+ transport through the cyclosporine A-sensitive mitochondrial permeability transition pore is discussed and an alternative mechanism for the mitochondrial pore opening, namely, formation of the lipid pore induced by saturated fatty acids, and its role in Ca2- transport are described in detail.
Journal ArticleDOI
Diabetes Mellitus, Mitochondrial Dysfunction and Ca2+-Dependent Permeability Transition Pore
Konstantin N. Belosludtsev,Konstantin N. Belosludtsev,Natalia V. Belosludtseva,Natalia V. Belosludtseva,Mikhail V. Dubinin +4 more
TL;DR: This review is dedicated to the analysis of recent data regarding the role of mitochondrial dysfunction in the development of diabetes mellitus and specific areas of focus include the involvement of mitochondrial calcium transport systems and a pathophysiological phenomenon called the permeability transition pore in the pathogenesis of Diabetes mellitus.
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Ca(2+)-dependent permeabilization of mitochondria and liposomes by palmitic and oleic acids: a comparative study.
Konstantin N. Belosludtsev,Natalia V. Belosludtseva,Alexey V. Agafonov,Maxim E. Astashev,Alexey S. Kazakov,Nils-Erik L. Saris,Galina D. Mironova +6 more
TL;DR: It is suggested that the cause of OA/Ca(2+)-induced permeability transition in mitochondria may be the fusion of the inner and outer mitochondrial membranes, suggesting that the probability of these mechanisms to be realized in the cell is high.
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On the mechanism of palmitic acid-induced apoptosis: the role of a pore induced by palmitic acid and Ca2+ in mitochondria.
Konstantin N. Belosludtsev,Nils-Erik L. Saris,Leif C. Andersson,Natalia V. Belosludtseva,Alexey V. Agafonov,Ankit Sharma,Dmitry A. Moshkov,Galina D. Mironova +7 more
TL;DR: Evidence is presented for the involvement of the mitochondrial cyclosporin A-insensitive pore induced by Pal/Ca2+ complexes in the apoptotic process and the specific probe for cardiolipin, 10-N-nonyl acridine orange, inhibited formation of this pore.
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Ca 2+ -Induced Phase Separation in the Membrane of Palmitate- Containing Liposomes and Its Possible Relation to Membrane Permeabilization
Alexey V. Agafonov,E. N. Gritsenko,Elena A. Shlyapnikova,Dmitry P. Kharakoz,Natalia V. Belosludtseva,Enrik I. Lezhnev,Nils-Erik L. Saris,Galina D. Mironova +7 more
TL;DR: A Ca2+-induced phase separation of palmitic acid in the membrane of azolectin unilamellar liposomes has been demonstrated with the fluorescent membrane probe nonyl acridine orange and it has been shown that NAO, whose fluorescence in liposomal membranes is quenched in a concentration-dependent way, can be used to monitor changes in the volume of lipid phase.