Showing papers by "Natalia V. Gulyaeva published in 1994"
TL;DR: Positive linear inter-regional cross-correlations of NOS activity as well as of FRG were found, and negative correlations between NOS, and FRG in cerebral cortex were revealed.
Abstract: WE have investigated the activity of NO synthase (NOS), and generation of free radicals (FRG) in selected brain regions of old male Wistar rats. Using the emotional resonance test, two groups of rats were selected for the experiment: passive, preferring dark space, and active, preferring light space. Highest NOS activity, and FRG were seen in cerebellum. As a rule, NOS activity was lower, and FRG higher in the respective brain regions of active rats than in passive rats. Positive linear inter-regional cross-correlations of NOS activity as well as of FRG were found. When all rats were assessed as one group, negative correlations between NOS, and FRG in cerebral cortex were revealed.
22 citations
TL;DR: Novel approaches to the management of cerebral disorders, based on the use of antioxidants, are considered, and it is shown that these reactions are of key importance to the damage sustained by cellular structures of the central nervous system.
Abstract: The current status of knowledge about the roles played by radical reactions in the pathogenesis of cerebral pathologies is reviewed, and it is shown that these reactions are of key importance to the damage sustained by cellular structures of the central nervous system. Novel approaches to the management of cerebral disorders, based on the use of antioxidants, are considered.
3 citations