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Nathalie de Parseval
Researcher at Institut Gustave Roussy
Publications - 8
Citations - 1204
Nathalie de Parseval is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Gene & Endogenous retrovirus. The author has an hindex of 8, co-authored 8 publications receiving 1124 citations. Previous affiliations of Nathalie de Parseval include Centre national de la recherche scientifique.
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Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.
TL;DR: The present data have identified a previously uncharacterized envelope with a potential role in placenta formation, and the identification of the complete set of retroviral envelopes with fusogenic properties allows a definite analysis of the possible role of HERV in this physiological process, via classical genetic approaches.
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Survey of Human Genes of Retroviral Origin: Identification and Transcriptome of the Genes with Coding Capacity for Complete Envelope Proteins
TL;DR: The complete sequencing of the human genome allowed a systematic search for retroviral envelope genes containing an open reading frame and resulted in the identification of 16 genes that are characterized, showing that all 16 genes are expressed in at least some healthy human tissues, albeit at highly different levels.
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The full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties.
TL;DR: The results emphasize the close relationship between endogenous and infectious retroviruses and might be important in relation to the process of tumour progression in humans.
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Functional characterization of two newly identified Human Endogenous Retrovirus coding envelope genes
TL;DR: Results suggest that at least one of these env genes may play a role in placentation, but most probably through a process different from that of the two previously identified syncytins.
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Physiological Knockout of the Envelope Gene of the Single-Copy ERV-3 Human Endogenous Retrovirus in a Fraction of the Caucasian Population
TL;DR: A natural knockout of ERV-3 provides a mean to investigate other potential roles for this otherwise highly conserved gene, potentially involved in important placental functions.