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Nathan Crook
Researcher at North Carolina State University
Publications - 39
Citations - 2016
Nathan Crook is an academic researcher from North Carolina State University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 17, co-authored 31 publications receiving 1593 citations. Previous affiliations of Nathan Crook include Washington University in St. Louis & University of Texas at Austin.
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The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation
TL;DR: This review summarizes current research on the short-term and long-term consequences of antibiotic use on the human microbiome, from early life to adulthood, and its effect on diseases such as malnutrition, obesity, diabetes, and Clostridium difficile infection.
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Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
TL;DR: The goal was to engineer a P450BM3 variant with nativelike activity and coupling efficiency towards a structurally challenging, nonnative substrate (propane) and evaluate the impact of these features on performance in preparative-scale biotransformations.
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Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties.
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Design of synthetic yeast promoters via tuning of nucleosome architecture
TL;DR: It is demonstrated that nucleosome architecture can play a role in defining yeast promoter activity and a computationally-guided approach is utilized that can enable both the redesign of endogenous promoter sequences and the de novo design of synthetic promoters.
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In vivo continuous evolution of genes and pathways in yeast.
TL;DR: This work synthetically optimize the retrotransposon Ty1 to enable in vivo generation of mutant libraries up to 1.6 × 107 l−1 per round, which is the highest of any in vivo mutational generation approach in yeast.