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Nathan J. Alves
Researcher at Indiana University
Publications - 58
Citations - 1363
Nathan J. Alves is an academic researcher from Indiana University. The author has contributed to research in topics: Drug delivery & Fibrin. The author has an hindex of 20, co-authored 51 publications receiving 1071 citations. Previous affiliations of Nathan J. Alves include University of Southern California & Purdue University.
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Journal ArticleDOI
Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy
Abhimanyu Paraskar,Shivani Soni,Kenneth T. Chin,Padmaparna Chaudhuri,Katherine W. Muto,Julia Berkowitz,Michael W. Handlogten,Nathan J. Alves,Basar Bilgicer,Daniela M. Dinulescu,R. A. Mashelkar,Shiladitya Sengupta +11 more
TL;DR: The rational engineering of a novel nanoplatinate inspired by the mechanisms underlying cisplatin bioactivation is reported, which exhibited significantly improved antitumor efficacy in terms of tumor growth delay in breast and lung cancers and tumor regression in a K-rasLSL/+/Ptenfl/fl ovarian cancer model.
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Bacterial Nanobioreactors–Directing Enzyme Packaging into Bacterial Outer Membrane Vesicles
Nathan J. Alves,Kendrick B. Turner,Michael A. Daniele,Eunkeu Oh,Igor L. Medintz,Scott A. Walper +5 more
TL;DR: The coexpression of OmpA-ST with PTE-SC greatly improved the overall PTE production levels by mitigating toxicity through exporting of the Pte-SC and greatly enhanced packaged enzyme stability against iterative cycles of freezing and thawing.
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Printed Graphene Electrochemical Biosensors Fabricated by Inkjet Maskless Lithography for Rapid and Sensitive Detection of Organophosphates
John A. Hondred,Joyce C. Breger,Nathan J. Alves,Scott A. Trammell,Scott A. Walper,Igor L. Medintz,Jonathan C. Claussen,Jonathan C. Claussen +7 more
TL;DR: A scalable printed graphene manufacturing technique that can be used to create OP biosensors that are suitable for in-field applications as well as, more generally, for low-cost biosensor test strips that could be incorporated into wearable or disposable sensing paradigms are presented.
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Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo.
Tanyel Kiziltepe,Jonathan D. Ashley,Jared F. Stefanick,Yu Meng Qi,Nathan J. Alves,Michael W. Handlogten,Mark A. Suckow,Rudolph M. Navari,Basar Bilgicer +8 more
TL;DR: The rational engineering of a multifunctional nanoparticle that combines traditional chemotherapy with cell targeting and anti-adhesion functionalities is reported, enabling the model of an integrative approach in the treatment of MM.
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Protecting enzymatic function through directed packaging into bacterial outer membrane vesicles
TL;DR: In this article, the authors exploit bacterial outer membrane vesicles (OMVs) to package and maintain the activity of an enzyme, phosphotriesterase (PTE), under challenging storage conditions encountered for real world applications.