Nausica Arnoult

TL;DR: Using cell lines of various origins, it is shown that telomere elongation consistently represses TERRA expression, and supports the existence of a negative-feedback mechanism in which longer TERRA moleculesRepression is mediated by increased trimethylated H3K9 density at telomeres and by heterochromatin protein HP1α, restricting human TPE to telomerre transcription.

TL;DR: It is found that slowing the replication speed triggers the recruitment of latent origins within minutes, allowing the completion of S phase in a timely fashion, suggesting a mechanism of origin programming in which replication speed determines the spacing of anchorage regions of chromatin loops, that, in turn, controls the choice of initiation sites.

TL;DR: The induction of ALT phenotypes as a consequence of ASF1 depletion strongly supports the hypothesis that ALT is a result of histone management dysfunction.

TL;DR: It is proposed that CYREN is a direct cell-cycle-dependent inhibitor of cNHEJ that promotes error-free repair by homologous recombination during cell cycle phases when sister chromatids are present.

TL;DR: This work focuses on mammalian telomeres and summarizes and interpret recent discoveries in detail, focusing on how repair pathways are inhibited, how resection and replication are controlled and how these mechanisms govern cell fate during senescence, crisis and transformation.