Geneviève Almouzni

TL;DR: Considering chromatin-based information, key candidates have arisen as epigenetic marks, including DNA and histone modifications, histone variants, non-histone chromatin proteins, nuclear RNA as well as higher-order chromatin organization.

TL;DR: The aim of this Review is to describe how nucleosome-assembly pathways and chromatin-maturation mechanisms that reproduce chromatin organization in the wake of DNA replication and repair operate and to highlight how the epigenetic landscape may be stably maintained even in the face of dramatic changes in chromatin structure.

TL;DR: The results show that both H3-K9 acetylation and methylation can occur on independent sets of H3 molecules in pericentric heterochromatin, and identify an RNA- and histone modification–dependent structure that brings methylated H1 protein–binding tails together in a specific configuration required for the accumulation of HP1 proteins in these domains.

TL;DR: It is suggested that the mechanism of histone replacement is critical for these chromatin rearrangements to occur, and the marked chromatin changes are intimately linked with genome-wide DNA demethylation.

TL;DR: Heterochromatin maintenance is crucial for the clonal inheritance of cell identity, to ensure the proper segregation of chromosomes and the regulation of gene expression, and recent progress has shed light on the paradoxical properties of heterochromaatin in the nucleus.