Naveen Mulakayala

TL;DR: A focused library of novel bis-heterocycles encompassing 2-mercapto benzothiazole and 1,2,3-triazoles including 4a, 4d, 4e and 4f posses significant anti-inflammatory activity as compared to the standard drug Ibuprofen.

TL;DR: Most of the compounds synthesized showed good anti-proliferative properties in vitro against three cancer cell lines and 9-(2-hydroxyphenyl)-3,3, 6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1,8(2H)-dione possessing a 2-hydroxy phenyl group at C-9 position was found to be promising.

TL;DR: Molecular docking studies of the active compounds reveal that these compounds are targeting DprE1 and may act as DPRE1 inhibitors and are completely killing the microbes at 32-64 μg/mL concentrations.

TL;DR: A clean process for the ipso-hydroxylation of aryl and heteroaryl boronic acids to the corresponding phenols using commercially available and recyclable Amberlite IR-120 resin and aqueous hydrogen peroxide as an oxidizing agent was developed in this paper.

TL;DR: To evaluate the role of COX-2 and 5-LOX as dual inhibitors in controlling the cancer cell proliferation, a set of two series of 42 compounds of 1, 2, 3-Tethered Indole-3-glyoxamide derivatives were synthesized by employing click chemistry approach and showed excellent to moderate anti-proliferative activity.