N
Neal A. Ladwa
Publications - 1
Citations - 203
Neal A. Ladwa is an academic researcher. The author has contributed to research in topics: Gp41 & Enfuvirtide. The author has an hindex of 1, co-authored 1 publications receiving 182 citations.
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Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency
Paolo Ingallinella,Elisabetta Bianchi,Neal A. Ladwa,Ying-Jie Wang,Renee Hrin,Maria Veneziano,Fabio Bonelli,Thomas J. Ketas,John P. Moore,Michael D. Miller,Antonello Pessi +10 more
TL;DR: C34 derivatized with cholesterol (C34- Chol) shows dramatically increased antiviral potency on a panel of primary isolates, with IC90 values 15- to 300-fold lower than enfuvirtide and the second-generation inhibitor T1249, making C34-Chol the most potent HIV fusion inhibitor to date.