Elisabetta Bianchi

TL;DR: Sustained GLP1R/GCGR dual agonism reverses obesity in DIO mice and is a novel therapeutic approach to the treatment of obesity.

TL;DR: It is reported that aggregates of NAC and α‐syn proteins induced apoptotic cell death in human neuroblastoma SH‐SY5Y cells, indicating that accumulation of α‐ Synuclein and its degradation products may play a major role in the development of the pathogenesis of these neurodegenerative diseases.

TL;DR: A novel method for the solid phase synthesis of thioesters by the most prevalent Fmoc/t-Bu method, based on the use of a 3-carboxypropanesulfonamide safety-catch linker, which is fully stable to repetitive exposure to the basic conditions needed for FmOC cleavage.

TL;DR: Human amino acid 186 was found to be critical for the interaction with the viral envelope glycoprotein E2, suggesting that this amino acid contributes to the tertiary structure of CD81 and its ligand-binding ability.

TL;DR: This work compared the gene-expression profiles of human Th1 and Th2 cells using high-density oligonucleotide arrays with the capacity to display transcript levels of 6,000 human genes and identified 215 differentially expressed genes, encoding proteins involved in transcriptional regulation, apoptosis, proteolysis, and cell adhesion and migration.