C
Chandanamali Punchihewa
Researcher at St. Jude Children's Research Hospital
Publications - 27
Citations - 4066
Chandanamali Punchihewa is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Wnt signaling pathway & PDZ domain. The author has an hindex of 18, co-authored 27 publications receiving 3446 citations. Previous affiliations of Chandanamali Punchihewa include University of Arizona.
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Journal ArticleDOI
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
Kristian W. Pajtler,Kristian W. Pajtler,Hendrik Witt,Martin Sill,David T.W. Jones,Volker Hovestadt,Fabian Kratochwil,Khalida Wani,Ruth G. Tatevossian,Chandanamali Punchihewa,Pascal Johann,Jüri Reimand,Hans-Jörg Warnatz,Marina Ryzhova,Steve Mack,Vijay Ramaswamy,David Capper,David Capper,Leonille Schweizer,Leonille Schweizer,Laura Sieber,Andrea Wittmann,Zhiqin Huang,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Daniel W. Fults,Helen Toledano,Smadar Avigad,Lindsey M. Hoffman,Andrew M. Donson,Nicholas K. Foreman,Ekkehard Hewer,Karel Zitterbart,Mark R. Gilbert,Terri S. Armstrong,Terri S. Armstrong,Nalin Gupta,Jeffrey C. Allen,Matthias A. Karajannis,David Zagzag,Martin Hasselblatt,Andreas E. Kulozik,Olaf Witt,V. Peter Collins,Katja von Hoff,Stefan Rutkowski,Torsten Pietsch,Gary D. Bader,Marie-Laure Yaspo,Andreas von Deimling,Andreas von Deimling,Peter Lichter,Michael D. Taylor,Richard J. Gilbertson,David W. Ellison,Kenneth Aldape,Andrey Korshunov,Andrey Korshunov,Marcel Kool,Stefan M. Pfister +61 more
TL;DR: The molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
Journal ArticleDOI
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
Jinghui Zhang,Gang Wu,Claudia P. Miller,Ruth G. Tatevossian,James Dalton,Bo Tang,Wilda Orisme,Chandanamali Punchihewa,Matthew Parker,Ibrahim Qaddoumi,F.A. Boop,Charles Lu,Cyriac Kandoth,Li Ding,Ryan P. Lee,Robert Huether,Xiang Chen,Erin Hedlund,Panduka Nagahawatte,Michael Rusch,Kristy Boggs,Jinjun Cheng,Jared Becksfort,Jing Ma,Guangchun Song,Yongjin Li,Lei Wei,Jianmin Wang,Sheila A. Shurtleff,John Easton,David Zhao,Robert S. Fulton,Lucinda Fulton,David J. Dooling,Bhavin Vadodaria,Heather L. Mulder,Chunlao Tang,Kerri Ochoa,Charles G. Mullighan,Amar Gajjar,Richard W. Kriwacki,Denise Sheer,Richard J. Gilbertson,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Suzanne J. Baker,David W. Ellison +47 more
TL;DR: Focusing on the therapeutically challenging diffuse LGGs, this study of 151 tumors has discovered genetic alterations and potential therapeutic targets across the entire range of pediatric L GGs and LGGNTs.
Journal ArticleDOI
C11orf95 – RELA fusions drive oncogenic NF-κB signalling in ependymoma
Matthew Parker,Kumarasamypet M. Mohankumar,Chandanamali Punchihewa,Ricardo Weinlich,James Dalton,Yongjin Li,Ryan P. Lee,Ruth G. Tatevossian,Timothy N. Phoenix,Radhika Thiruvenkatam,Elsie White,Bo Tang,Wilda Orisme,Kirti Gupta,Michael Rusch,Xiang Chen,Yuxin Li,Panduka Nagahawhatte,Erin Hedlund,David Finkelstein,Gang Wu,Sheila A. Shurtleff,John Easton,Kristy Boggs,Donald Yergeau,Bhavin Vadodaria,Heather L. Mulder,Jared Becksford,Pankaj Gupta,Robert Huether,Jing Ma,Guangchun Song,Amar Gajjar,Thomas E. Merchant,Frederick A. Boop,Amy A Smith,Li Ding,Charles Lu,Kerri Ochoa,David Zhao,Robert S. Fulton,Lucinda Fulton,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Douglas R. Green,Jinghui Zhang,David W. Ellison,Richard J. Gilbertson +48 more
TL;DR: The data identify a highly recurrent genetic alteration of RELA in human cancer, and the C11orf95–RELA fusion protein as a potential therapeutic target in supratentorial ependymoma.
Journal ArticleDOI
Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence
TL;DR: The first structure of the major intramolecular G-quadruplex formed in a native, non-modified human telomeric sequence in K+ solution is reported, a hybrid-type mixed parallel/antiparallel-G-stranded G- quadruplex, one end of which is covered by a novel T:A:T triple capping structure.
Journal ArticleDOI
Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation
TL;DR: The study indicates that the three loop regions interact with the core G-tetrads in a specific way that defines and stabilizes the unique human telomeric G-quadruplex structure in K+, suggesting that it can be specifically targeted for anticancer drug design.