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Neil E. Lamb
Researcher at Emory University
Publications - 36
Citations - 2307
Neil E. Lamb is an academic researcher from Emory University. The author has contributed to research in topics: Nondisjunction & Population. The author has an hindex of 18, co-authored 36 publications receiving 2102 citations. Previous affiliations of Neil E. Lamb include Joint Genome Institute.
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Journal ArticleDOI
Susceptible chiasmate configurations of chromosome 21 predispose to non-disjunction in both maternal meiosis I and meiosis II
Neil E. Lamb,Sallie B. Freeman,Amanda Savage-Austin,Dorothy Pettay,Lisa Taft,Jane Hersey,Yuanchao Gu,Joseph J. Shen,Denise Saker,Kristen M. May,Dimitris Avramopoulos,Michael B. Petersen,Anni Hallberg,Margareta Mikkelsen,Terry J. Hassold,Stephanie L. Sherman,Stephanie L. Sherman +16 more
TL;DR: These findings profoundly affect the understanding of trisomy 21 as they suggest that virtually all maternal non–disjunction results from events occurring in meioisis I.
Journal ArticleDOI
Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer
Weidong Zhao,Irfan M Hisamuddin,Mandayam O. Nandan,Brian A. Babbin,Neil E. Lamb,Vincent W. Yang +5 more
TL;DR: It is shown that KLF4 is a potential tumor suppressor gene in CRC, and evidence is found for loss of heterozygosity in two of eight surgically resected CRC specimens.
Journal ArticleDOI
Characterization of Susceptible Chiasma Configurations that Increase the Risk for Maternal Nondisjunction of Chromosome 21
Neil E. Lamb,Eleanor Feingold,Amanda Savage,Dimitris Avramopoulos,Sallie B. Freeman,Yuanchao Gu,Anni Hallberg,Jane Hersey,Georgia Karadima,Dorothy Pettay,Denise Saker,Joseph J. Shen,Lisa Taft,Margareta Mikkelsen,Michael B. Petersen,Terry J. Hassold,Stephanie L. Sherman +16 more
TL;DR: Data suggest that the location of certain exchanges makes a tetrad susceptible to non-disjunction, and this susceptibility is associated with the distance between the centromere and closest exchange.
Journal ArticleDOI
Recombination rate and reproductive success in humans
Augustine Kong,John Barnard,Daniel F. Gudbjartsson,Gudmar Thorleifsson,Gudrun M. Jonsdottir,Sigrun Sigurdardottir,Bjorgvin Richardsson,Jonina Jonsdottir,Thorgeir E. Thorgeirsson,Michael L. Frigge,Neil E. Lamb,Stephanie L. Sherman,Jeffrey R. Gulcher,Kari Stefansson +13 more
TL;DR: This work examined genome-wide microsatellite data for 23,066 individuals, providing information on recombination events of 14,140 maternal and paternal meioses each, and found a positive correlation between maternal recombination counts of an offspring and maternal age.
Journal ArticleDOI
Effect of meiotic recombination on the production of aneuploid gametes in humans
TL;DR: Significant alterations in recombination have been found for all meiosis I-derived trisomies studied to date and a subset of so called “meiosis II” trisomy, suggesting an association may exist between recombination and maternal age, the most widely identified risk factor for aneuploidy.