N
Neil Howell
Researcher at University of Texas Medical Branch
Publications - 115
Citations - 12752
Neil Howell is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Mitochondrial DNA & Human mitochondrial genetics. The author has an hindex of 54, co-authored 111 publications receiving 12226 citations. Previous affiliations of Neil Howell include University of Texas at Austin & Newcastle University.
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Journal ArticleDOI
Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA
Journal ArticleDOI
Reduced-Median-Network Analysis of Complete Mitochondrial DNA Coding-Region Sequences for the Major African, Asian, and European Haplogroups
Corinna Herrnstadt,Joanna L. Elson,Eoin Fahy,Gwen Preston,Douglass M. Turnbull,Christen M. Anderson,Soumitra S. Ghosh,Jerrold M. Olefsky,M. Flint Beal,Robert E. Davis,Neil Howell +10 more
TL;DR: This work used reduced-median-network approaches to analyze 560 complete European, Asian, and African mtDNA coding-region sequences from unrelated individuals to develop a more complete understanding of sequence diversity both within and between haplogroups.
Journal ArticleDOI
Mammalian mitochondrial genetics: heredity, heteroplasmy and disease
TL;DR: How much there is still to learn about mitochondrial genetics is reiterated to discuss recent observations that have addressed several fundamental issues and to predict the segregation and transmission of a mutant genome.
Journal ArticleDOI
The epidemiology of Leber hereditary optic neuropathy in the North East of England.
Patrick Yu Wai Man,Philip G. Griffiths,D. T. Brown,Neil Howell,Douglass M. Turnbull,Patrick F. Chinnery +5 more
TL;DR: The first population-based clinical and molecular genetic study of Leber hereditary optic neuropathy in a population of 2,173,800 individuals in the North East of England indicates that LHON is not rare but has a population prevalence similar to autosomally inherited neurological disorders.
Journal Article
Leber Hereditary Optic Neuropathy: Identification of the Same Mitochondrial ND1 Mutation in Six Pedigrees
Neil Howell,Laurence A. Bindoff,D A McCullough,I Kubacka,Joanna Poulton,David A. Mackey,L Taylor,D M Turnbull +7 more
TL;DR: Biochemical and molecular genetic evidence is presented that in six independent pedigrees the development of Leber hereditary optic neuropathy (LHON) is due to the same primary mutation in the mitochondrial ND1 gene.