Showing papers by "Neil R. Smalheiser published in 1984"
TL;DR: Laminin, a glycoprotein found in basement membranes and adhesion sites of a variety of cell types, acted as a substrate for retinal explant attachment and axonal outgrowth when axons were given a direct choice, and laminin was preferred over collagen.
162 citations
TL;DR: Evidence is reviewed that "sibling neurite bias" may contribute to the establishment and stabilization of specific neural connections and specific examples examined include the loss of polyinnervation at the developing neuromuscular junction, contextual mapping in the retino-tectal system, and selective neurite growth patterns and synaptic connections in nerve tissue culture model systems.
Abstract: In this review we consider a novel mechanism, "sibling neurite bias," which may explain aspects of the coordination of elongation, branching, and resorption among different neurites growing from the same neuronal cell body. In this model, growing neurites which incorporate structural precursors at higher rates would deplete the cellular pool of precursors available to their "sibling" neurites; neurites would compete for survival, but in addition they would bias each other's behavior during active growth. Evidence is reviewed that "sibling neurite bias" may contribute to the establishment and stabilization of specific neural connections. Specific examples examined include the loss of polyinnervation at the developing neuromuscular junction, contextual mapping in the retino-tectal system, and selective neurite growth patterns and synaptic connections in nerve tissue culture model systems.
60 citations
TL;DR: It is concluded that the in situ central-to-peripheral sequence of cellular differentiation continues in vitro within retinal explants, and it is suggested that disintegration of individual axons in the outgrowth may occur rapidly and in a central- to-per peripheral sequence.
4 citations