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Neil Singla
Researcher at Huntington Hospital
Publications - 70
Citations - 2597
Neil Singla is an academic researcher from Huntington Hospital. The author has contributed to research in topics: Placebo & Analgesic. The author has an hindex of 25, co-authored 68 publications receiving 2307 citations.
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Journal ArticleDOI
Plasma and Cerebrospinal Fluid Pharmacokinetic Parameters after Single-Dose Administration of Intravenous, Oral or Rectal Acetaminophen
Neil Singla,Cherri Parulan,Roselle Samson,Joel Hutchinson,Rick Bushnell,Evelyn G. Beja,Robert Y. Ang,Mike A. Royal +7 more
TL;DR: This is the first study to compare plasma and cerebrospinal fluid (CSF) pharmacokinetics of intravenous (IV), oral (PO), or rectal (PR) formulations of acetaminophen.
Journal ArticleDOI
Pharmacokinetic Profile of Liposome Bupivacaine Injection Following a Single Administration at the Surgical Site
TL;DR: Liposome bupivacaine was well tolerated across the four studies and varied surgical models, and exhibited bimodal kinetics with rapid uptake observed during the first few hours and prolonged release through 96 h after administration.
Journal ArticleDOI
A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting.
Tong J. Gan,Christian C. Apfel,Anthony L. Kovac,Beverly K. Philip,Neil Singla,Harold S. Minkowitz,Ashraf S. Habib,Jennifer Knighton,Alexandra D. Carides,Hong Zhang,Kevin J. Horgan,Judith K. Evans,Francasca C. Lawson,Farshad Ahadian,David Andres,J. Todd S. Blood,Keith A. Candiotti,Jacques E. Chelly,Paul Cook,Robert D'Angelo,Donald Edmondson,Lee A. Fleisher,Joo Gan Tong,Ralf E. Gebhard,Kevin J. Gingrich,Jeffrey A. Grass,Scott B. Groudine,John Hatridge,Timothy Houden,Michael B. Howie,Piotr K. Janicki,Daniel Katz,Bupesh Kaul,Robert M. Knapp,A. Kovac,Kathryn K. Lauer,J. Lance Lichtor,Timothy I. Melson,Kelly J. Myers,Peter H. Norman,Michael H. Pearman,James H. Philip,Neil K. Singla,Marvin Tark,Paul F. White,Thomas A. Witkowski +45 more
TL;DR: Aprepitant was superior to ondansetron for prevention of vomiting in the first 24 and 48 h, but no significant differences were observed between aprepitant and ondANSetronFor nausea control, use of rescue, or complete response.
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A phase 3, randomized, double-blind comparative study of the efficacy and safety of topical recombinant human thrombin and bovine thrombin in surgical hemostasis.
William C. Chapman,Neil Singla,Yuri Genyk,James W. McNeil,Kenneth L. Renkens,Thomas Reynolds,Aileen Murphy,Fred A. Weaver +7 more
TL;DR: Results of this trial suggest that rhThrombin has comparable efficacy, a similar safety profile, and is considerably less immunogenic than bovine thrombin when used for surgical hemostasis.
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Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery.
Nancy A. Nussmeier,Andrew Whelton,Mark T. Brown,Girish P. Joshi,Richard M. Langford,Neil Singla,Mark E. Boye,Kenneth M. Verburg +7 more
TL;DR: Parecoxib and valdecoxib are useful adjuncts to opioids for the treatment of postoperative pain in noncardiac surgical patients and further study will be required to determine the safety profile of parecoxIB and valDecoxib administered to patients with known atherosclerotic disease after non Cardiac surgery.